Gulp1 MGI Mouse Gene Detail - MGI:1920407 - GULP, engulfment adaptor PTB domain containing 1

Symbol

Gulp1
Name

GULP, engulfment adaptor PTB domain containing 1
Synonyms

3110030A04Rik, 5730529O06Rik, Ced6, CED-6, GULP

Feature Type

protein coding gene
IDs

MGI:1920407
NCBI Gene: 70676
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:44590671-44835998 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 23.63 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

7862 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920407	protein coding gene	Chr1:44590540-44835998 (+)
129S1/SvImJ	ENSMUSG00200001382	protein coding gene	Chr1:42229423-42466058 (+)
A/J	ENSMUSG00195001848	protein coding gene	Chr1:41959151-42196135 (+)
AKR/J	ENSMUSG00220002930	protein coding gene	Chr1:41915710-42151707 (+)
BALB/cJ	ENSMUSG00180003095	protein coding gene	Chr1:41936842-42182166 (+)
C3H/HeJ	ENSMUSG00175000050	protein coding gene	Chr1:41994367-42231325 (+)
C57BL/6NJ	ENSMUSG00215002963	protein coding gene	Chr1:41915198-42160524 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014104	protein coding gene	Chr1:39035802-39260283 (+)
CAST/EiJ	ENSTCUG00005000588	protein coding gene	Chr1:41966817-42197229 (+)
CBA/J	ENSMUSG00210027318	protein coding gene	Chr1:41672463-41909396 (+)
DBA/2J	ENSMUSG00185028886	protein coding gene	Chr1:42813823-43050772 (+)
FVB/NJ	ENSMUSG00205003455	protein coding gene	Chr1:41860825-42096807 (+)
JF1/MsJ	ENSUMUG00000000874	protein coding gene	Chr1:41921076-42160339 (+)
LP/J	ENSMUSG00230000828	protein coding gene	Chr1:42822362-43067676 (+)
NOD/ShiLtJ	ENSMUSG00190002404	protein coding gene	Chr1:41886997-42122968 (+)
NZO/HlLtJ	ENSMUSG00225000274	protein coding gene	Chr1:46057460-46302785 (+)
PWK/PhJ	ENSLUMG00010002278	protein coding gene	Chr1:41468169-41691204 (+)
SPRET/EiJ	ENSMSPG00010012236	protein coding gene	Chr1:43111415-43370570 (+)
WSB/EiJ	ENSIUOG00005003467	protein coding gene	Chr1:41818486-42052432 (+)

Human Ortholog

GULP1, GULP PTB domain containing engulfment adaptor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GULP1, GULP PTB domain containing engulfment adaptor 1
Synonyms

CED-6, CED6, GULP
Links

HGNC:18649

NCBI Gene ID: 51454

UniProt: Q9UBP9
Chr Location

2q32.1-q32.2; chr2:188291105-188595943 (+) GRCh38

MGI Vertebrate Homology

Gulp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GULP1
Gene Tree

Gulp1

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

4
Genomic Mutations

1 involving Gulp1
Incidental Mutations

APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null mutation show increased bone mass and impaired osteoclast differentiation and function.

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All GO Annotations

7
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

94
cDNA Data

26
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gulp1

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All Sequences

59
RefSeq

10
UniProt

5
CCDS

CCDS48250.1

Ensembl

ENSMUSG00000056870 (Evidence)
NCBI Gene

70676

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056870	Ensembl Gene Model \| MGI Sequence Detail	245328	C57BL/6J	± kb
transcript	ENSMUST00000160854	Ensembl \| MGI Sequence Detail	1399	Not Applicable
polypeptide	ENSMUSP00000125506	Ensembl \| MGI Sequence Detail	309	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008357 PTB domain-containing engulfment adapter protein 1

(term hierarchy)
InterPro Domains

IPR051133 Adapter and Engulfment Domain-Containing Protein

IPR011993 PH-like domain superfamily

IPR006020 PTB/PI domain
GlyGen

Q8K2A1 1 site, 1 N-linked glycan (1 site)

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All nucleic 26

cDNA 26

Microarray probesets 5

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MGI:1917926

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:370232 Kim D, et al., Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF-beta/SMAD2/3 pathway. FEBS Lett. 2024 Apr;598(8):935-944

TSS for Gulp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6568	Chr1:44590643-44590659 (+)	-20 bp
Tssr6569	Chr1:44590720-44590726 (+)	52 bp
Tssr6570	Chr1:44590810-44590864 (+)	166 bp
Tssr6571	Chr1:44590871-44590874 (+)	202 bp
Tssr6572	Chr1:44590879-44590886 (+)	212 bp
Tssr6573	Chr1:44590908-44590918 (+)	242 bp
Tssr6574	Chr1:44691612-44691616 (+)	100,943 bp
Tssr6575	Chr1:44828557-44828560 (+)	237,888 bp
Tssr6576	Chr1:44834862-44834907 (+)	244,214 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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