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Cenpv Gene Detail
Summary
  • Symbol
    Cenpv
  • Name
    centromere protein V
  • Synonyms
    3110013H01Rik, Prr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920389
    NCBI Gene: 73139
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:62415772-62430087 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 38.43 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    840 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920389
 protein coding gene Chr11:62415770-62430695 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018455
 protein coding gene Chr11:62570051-62585597 (-)
A/J MGP_AJ_G0018424
 protein coding gene Chr11:60257752-60272057 (-)
AKR/J MGP_AKRJ_G0018394
 protein coding gene Chr11:62116020-62130884 (-)
BALB/cJ MGP_BALBcJ_G0018395
 protein coding gene Chr11:60539503-60554145 (-)
C3H/HeJ MGP_C3HHeJ_G0018208
 protein coding gene Chr11:62095367-62110508 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018847
 protein coding gene Chr11:64536196-64560098 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016493
 protein coding gene Chr11:57354836-57367251 (-)
CAST/EiJ MGP_CASTEiJ_G0017765
 protein coding gene Chr11:62231874-62250151 (-)
CBA/J MGP_CBAJ_G0018182
 protein coding gene Chr11:67339696-67353993 (-)
DBA/2J MGP_DBA2J_G0018291
 protein coding gene Chr11:59816598-59832002 (-)
FVB/NJ MGP_FVBNJ_G0018282
 protein coding gene Chr11:59482885-59497748 (-)
LP/J MGP_LPJ_G0018364
 protein coding gene Chr11:63119349-63134918 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018306
 protein coding gene Chr11:68325591-68339788 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018888
 protein coding gene Chr11:62268332-62282698 (-)
PWK/PhJ MGP_PWKPhJ_G0017538
 protein coding gene Chr11:60434529-60449266 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017328
 protein coding gene Chr11:62118428-62132332 (-)
WSB/EiJ MGP_WSBEiJ_G0017817
 protein coding gene Chr11:61883038-61897417 (-)



Homology
more
  • Human Ortholog
    CENPV, centromere protein V
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPV, centromere protein V
  • Synonyms
    3110013H01Rik, CENP-V, p30, PRR6
  • Links
    NCBI Gene ID: 201161
    UniProt: Q7Z7K6

  • Chr Location
    17p11.2; chr17:16342534-16353656 (-)  GRCh38
  • Human Ortholog
    CENPVL3, centromere protein V like 3
  • Synonyms
    CENPVP3
  • Links
    NCBI Gene ID: 347549
    UniProt: A0A0U1RRI6

  • Chr Location
    Xp11.22; chrX:51617020-51618912 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced female fertility associated with abnormal female meiosis and meitotic spindle integrity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018509 Ensembl Gene Model | MGI Sequence Detail 14316 C57BL/6J ±  kb
    transcript ENSMUST00000018653 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    polypeptide ENSMUSP00000018653 Ensembl | MGI Sequence Detail 252 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3034506
    References
    more
    • Summaries
      All 40
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory