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Lonrf2 Gene Detail
Summary
  • Symbol
    Lonrf2
  • Name
    LON peptidase N-terminal domain and ring finger 2
  • Synonyms
    2900060P06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920209
    NCBI Gene: 381338
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:38832750-38875768 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 17.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1537 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920209
 protein coding gene Chr1:38832726-38875792 (-)
129S1/SvImJ ENSMUSG00200004200
 protein coding gene Chr1:36423448-36466460 (-)
A/J ENSMUSG00195041600
 protein coding gene Chr1:36081917-36124916 (-)
AKR/J ENSMUSG00220007832
 protein coding gene Chr1:36087796-36130800 (-)
BALB/cJ ENSMUSG00180010877
 protein coding gene Chr1:36165127-36208230 (-)
C3H/HeJ ENSMUSG00175001312
 protein coding gene Chr1:36085509-36128513 (-)
C57BL/6NJ ENSMUSG00215013290
 protein coding gene Chr1:36146510-36189617 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014064
 protein coding gene Chr1:33423427-33465951 (-)
CAST/EiJ ENSTCUG00005002831
 protein coding gene Chr1:36214616-36256798 (-)
CBA/J ENSMUSG00210005060
 protein coding gene Chr1:35899849-35942873 (-)
DBA/2J ENSMUSG00185009993
 protein coding gene Chr1:37003312-37046679 (-)
FVB/NJ ENSMUSG00205023243
 protein coding gene Chr1:36094720-36137768 (-)
JF1/MsJ ENSUMUG00000007274
 protein coding gene Chr1:36196024-36239394 (-)
LP/J ENSMUSG00230025167
 protein coding gene Chr1:37044606-37087626 (-)
NOD/ShiLtJ ENSMUSG00190036238
 protein coding gene Chr1:36116161-36159162 (-)
NZO/HlLtJ ENSMUSG00225013617
 protein coding gene Chr1:40291297-40335066 (-)
PWK/PhJ ENSLUMG00010031371
 protein coding gene Chr1:35734435-35777676 (-)
SPRET/EiJ ENSMSPG00010026622
 protein coding gene Chr1:37209035-37253620 (-)
WSB/EiJ ENSIUOG00005037028
 protein coding gene Chr1:36039385-36082453 (-)



Homology
more
  • Human Ortholog
    LONRF2, LON peptidase N-terminal domain and ring finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LONRF2, LON peptidase N-terminal domain and ring finger 2
  • Synonyms
    RNF192
  • Links
    NCBI Gene ID: 164832
    UniProt: Q1L5Z9

  • Chr Location
    2q11.2; chr2:100271875-100322501 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    662
  • Tissues
    10
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381338 NCBI Gene Model | MGI Sequence Detail 43019 C57BL/6J ±  kb
    transcript NM_001029878 RefSeq | MGI Sequence Detail 6884 C57BL/6  
    polypeptide NP_001025049 RefSeq | MGI Sequence Detail 754 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR003111 Lon protease, N-terminal domain
      IPR046336 Lon protease, N-terminal domain superfamily
      IPR015947 PUA-like superfamily
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013083 Zinc finger, RING/FYVE/PHD-type
      IPR001841 Zinc finger, RING-type
      IPR017907 Zinc finger, RING-type, conserved site
    • GlyGen
      F6ZE64 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138355
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory