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Tppp Gene Detail
Summary
  • Symbol
    Tppp
  • Name
    tubulin polymerization promoting protein
  • Synonyms
    2900041A09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920198
    NCBI Gene: 72948
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74157538-74183872 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920198
 protein coding gene Chr13:74157526-74183872 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020757
 protein coding gene Chr13:74501841-74528163 (+)
A/J MGP_AJ_G0020713
 protein coding gene Chr13:71835311-71861636 (+)
AKR/J MGP_AKRJ_G0020687
 protein coding gene Chr13:74085362-74113690 (+)
BALB/cJ MGP_BALBcJ_G0020710
 protein coding gene Chr13:72330694-72357022 (+)
C3H/HeJ MGP_C3HHeJ_G0020504
 protein coding gene Chr13:73772243-73801045 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021147
 protein coding gene Chr13:76977791-77004113 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018714
 protein coding gene Chr13:68657249-68684861 (+)
CAST/EiJ MGP_CASTEiJ_G0020021
 protein coding gene Chr13:72847578-72875885 (+)
CBA/J MGP_CBAJ_G0020463
 protein coding gene Chr13:79835088-79861425 (+)
DBA/2J MGP_DBA2J_G0020588
 protein coding gene Chr13:71654427-71680734 (+)
FVB/NJ MGP_FVBNJ_G0020568
 protein coding gene Chr13:70679897-70706231 (+)
LP/J MGP_LPJ_G0020661
 protein coding gene Chr13:74738408-74764730 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020596
 protein coding gene Chr13:78244103-78270409 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021186
 protein coding gene Chr13:73409836-73436170 (+)
PWK/PhJ MGP_PWKPhJ_G0019775
 protein coding gene Chr13:70393596-70420649 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019598
 protein coding gene Chr13:69880073-69912746 (+)
WSB/EiJ MGP_WSBEiJ_G0020079
 protein coding gene Chr13:73960518-73988220 (+)



Homology
more
  • Human Ortholog
    TPPP, tubulin polymerization promoting protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPPP, tubulin polymerization promoting protein
  • Synonyms
    p24, p25, p25alpha, TPPP1, TPPP/p25
  • Links
    NCBI Gene ID: 11076
    neXtProt AC: NX_O94811
    UniProt: O94811

  • Chr Location
    5p15.33; chr5:659862-700727 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    841
  • Tissues
    46
  • cDNA Data
    35
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72948 NCBI Gene Model | MGI Sequence Detail 26335 C57BL/6J ±  kb
    transcript NM_182839 RefSeq | MGI Sequence Detail 5108 C57BL/6  
    polypeptide Q7TQD2 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 35

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145302
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:339006 Endres T, et al., In vivo impact of tubulin polymerization promoting protein (Tppp) knockout to the airway inflammatory response. Sci Rep. 2023 Jul 28;13(1):12272
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory