About   Help   FAQ
Tbc1d5 Gene Detail
Summary
  • Symbol
    Tbc1d5
  • Name
    TBC1 domain family, member 5
  • Synonyms
    1600014N05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919488
    NCBI Gene: 72238
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:51040152-51486380 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 26.47 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10071 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919488
 protein coding gene Chr17:51040152-51488228 (-)
129S1/SvImJ ENSMUSG00200026432
 protein coding gene Chr17:46255992-46714488 (-)
A/J ENSMUSG00195020008
 protein coding gene Chr17:47736150-48187888 (-)
AKR/J ENSMUSG00220030668
 protein coding gene Chr17:46736172-47187899 (-)
BALB/cJ ENSMUSG00180022492
 protein coding gene Chr17:47492429-47944164 (-)
C3H/HeJ ENSMUSG00175014935
 protein coding gene Chr17:46799795-47251490 (-)
C57BL/6NJ ENSMUSG00215029432
 protein coding gene Chr17:46368556-46816828 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021737
 protein coding gene Chr17:47468744-47931774 (-)
CAST/EiJ ENSTCUG00005022763
 protein coding gene Chr17:47551238-48019525 (-)
CBA/J ENSMUSG00210034992
 protein coding gene Chr17:46549329-47001025 (-)
DBA/2J ENSMUSG00185027640
 protein coding gene Chr17:49448471-49900158 (-)
FVB/NJ ENSMUSG00205051585
 protein coding gene Chr17:47027654-47481726 (-)
JF1/MsJ ENSUMUG00000035038
 protein coding gene Chr17:49144220-49614515 (-)
LP/J ENSMUSG00230040291
 protein coding gene Chr17:50367476-50825946 (-)
NOD/ShiLtJ ENSMUSG00190015644
 protein coding gene Chr17:46525360-46977029 (-)
NZO/HlLtJ ENSMUSG00225042039
 protein coding gene Chr17:52592035-53050529 (-)
PWK/PhJ ENSLUMG00010033089
 protein coding gene Chr17:46378814-46834622 (-)
SPRET/EiJ ENSMSPG00010036649
 protein coding gene Chr17:46571830-47048223 (-)
WSB/EiJ ENSIUOG00005025926
 protein coding gene Chr17:47414987-47874512 (-)



Homology
more
  • Human Ortholog
    TBC1D5, TBC1 domain family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D5, TBC1 domain family member 5
  • Links
    NCBI Gene ID: 9779
    UniProt: Q92609

  • Chr Location
    3p24.3; chr3:17157162-18444817 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    7
  • cDNA Data
    51
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023923 Ensembl Gene Model | MGI Sequence Detail 446229 C57BL/6J ±  kb
    transcript ENSMUST00000224528 Ensembl | MGI Sequence Detail 4764 Not Applicable  
    polypeptide ENSMUSP00000153172 Ensembl | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016119 TBC1 domain family member 5
      (term hierarchy)
    • InterPro Domains
      IPR052145 Mediator complex and homeobox domain-containing protein
      IPR000195 Rab-GAP-TBC domain
      IPR035969 Rab-GAP-TBC domain superfamily
    • GlyGen
      Q80XQ2 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 53

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:79264 Cohen-Tannoudji M, et al., Unexpected position-dependent expression of H-2 and beta 2-microglobulin/lacZ transgenes. Mol Reprod Dev. 1992 Oct;33(2):149-59
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory