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Krt33a Gene Detail
Summary
  • Symbol
    Krt33a
  • Name
    keratin 33A
  • Synonyms
    2310015J09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919138
    NCBI Gene: 71888
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99902025-99907038 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.35 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919138
 protein coding gene Chr11:99902021-99907038 (-)
129S1/SvImJ ENSMUSG00200051400
 protein coding gene Chr11:97165664-97170675 (-)
A/J ENSMUSG00195048055
 protein coding gene Chr11:96854965-96859966 (-)
AKR/J ENSMUSG00220051060
 protein coding gene Chr11:97107263-97112274 (-)
BALB/cJ ENSMUSG00180045296
 protein coding gene Chr11:97236232-97241242 (-)
C3H/HeJ ENSMUSG00175050758
 protein coding gene Chr11:97139220-97144231 (-)
C57BL/6NJ ENSMUSG00215052292
 protein coding gene Chr11:96720957-96725974 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017152
 protein coding gene Chr11:95870376-95875435 (-)
CAST/EiJ ENSTCUG00005047974
 protein coding gene Chr11:96641525-96646531 (-)
CBA/J ENSMUSG00210051785
 protein coding gene Chr11:96869591-96874601 (-)
DBA/2J ENSMUSG00185051408
 protein coding gene Chr11:97189101-97194112 (-)
FVB/NJ ENSMUSG00205028885
 protein coding gene Chr11:97044289-97049300 (-)
JF1/MsJ ENSUMUG00000053968
 protein coding gene Chr11:97448919-97453957 (-)
LP/J ENSMUSG00230050809
 protein coding gene Chr11:98241873-98246884 (-)
NOD/ShiLtJ ENSMUSG00190039988
 protein coding gene Chr11:97223958-97228969 (-)
NZO/HlLtJ ENSMUSG00225050219
 protein coding gene Chr11:100286442-100291452 (-)
PWK/PhJ ENSLUMG00010040732
 protein coding gene Chr11:97005361-97010333 (-)
SPRET/EiJ ENSMSPG00010049386
 protein coding gene Chr11:97495783-97500776 (-)
WSB/EiJ ENSIUOG00005047713
 protein coding gene Chr11:96996505-97001506 (-)



Homology
more
  • Human Ortholog
    KRT33A, keratin 33A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT33A, keratin 33A
  • Synonyms
    Ha-3I, HA3I, hHa3-I, K33A, Krt1-3, KRTHA3A
  • Links
    NCBI Gene ID: 3883
    UniProt: O76009

  • Chr Location
    17q21.2; chr17:41346092-41350828 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations of this gene cause the hair coat to appear either shiny, reflective and "polished" or greasy looking, disheveled and "spikey."
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    24
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71888 NCBI Gene Model | MGI Sequence Detail 5014 C57BL/6J ±  kb
    transcript NM_027983 RefSeq | MGI Sequence Detail 1679 C57BL/6  
    polypeptide Q8K0Y2 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR002957 Keratin, type I
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory