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Cenpu Gene Detail
Summary
  • Symbol
    Cenpu
  • Name
    centromere protein U
  • Synonyms
    1700029A22Rik, Mlf1ip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919126
    NCBI Gene: 71876
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:47005063-47033042 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.38 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919126
protein coding gene Chr8:47005054-47033603 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033589
protein coding gene Chr8:45655640-45684050 (+)
A/J MGP_AJ_G0033571
protein coding gene Chr8:43906205-43934160 (+)
AKR/J MGP_AKRJ_G0033496
protein coding gene Chr8:45189465-45218994 (+)
BALB/cJ MGP_BALBcJ_G0033568
protein coding gene Chr8:44075491-44103897 (+)
C3H/HeJ MGP_C3HHeJ_G0033277
protein coding gene Chr8:45717437-45747169 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034084
protein coding gene Chr8:47387043-47418299 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031033
protein coding gene Chr8:40146622-40170950 (+)
CAST/EiJ MGP_CASTEiJ_G0032603
protein coding gene Chr8:45147186-45179306 (+)
CBA/J MGP_CBAJ_G0033256
protein coding gene Chr8:49273282-49306902 (+)
DBA/2J MGP_DBA2J_G0033409
protein coding gene Chr8:43700781-43728664 (+)
FVB/NJ MGP_FVBNJ_G0033350
protein coding gene Chr8:43176090-43204442 (+)
LP/J MGP_LPJ_G0033497
protein coding gene Chr8:45668384-45703156 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033395
protein coding gene Chr8:49375166-49403064 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034102
protein coding gene Chr8:45343981-45372664 (+)
PWK/PhJ MGP_PWKPhJ_G0032311
protein coding gene Chr8:43223267-43252507 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032147
protein coding gene Chr8:44509562-44537584 (+)
WSB/EiJ MGP_WSBEiJ_G0032719
protein coding gene Chr8:45605789-45634627 (+)



Homology
more
  • Human Ortholog
    CENPU, centromere protein U
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPU, centromere protein U
  • Synonyms
    CENP50, CENPU50, KLIP1, MLF1IP, PBIP1
  • Links
    NCBI Gene ID: 79682
    neXtProt AC: NX_Q71F23
    UniProt: Q71F23

  • Chr Location
    4q35.1; chr4:184694085-184734130 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E9.5, small embryo size and thickened visceral endoderm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031629 Ensembl Gene Model | MGI Sequence Detail 27980 C57BL/6J ±  kb
    transcript ENSMUST00000034045 Ensembl | MGI Sequence Detail 2931 Not Applicable  
    polypeptide ENSMUSP00000034045 Ensembl | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:338156 Tian T, et al., Structural insights into human CCAN complex assembled onto DNA. Cell Discov. 2022 Sep 9;8(1):90

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory