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Plekhf2 Gene Detail
Summary
  • Symbol
    Plekhf2
  • Name
    pleckstrin homology and FYVE domain containing 2
  • Synonyms
    1110070J07Rik, ZFYVE18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919051
    NCBI Gene: 71801
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:10988662-11007619 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 4.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    649 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919051
 protein coding gene Chr4:10988662-11007927 (-)
129S1/SvImJ ENSMUSG00200001271
 protein coding gene Chr4:7626490-7645608 (-)
A/J ENSMUSG00195002536
 protein coding gene Chr4:8063943-8083018 (-)
AKR/J ENSMUSG00220001010
 protein coding gene Chr4:7812105-7831383 (-)
BALB/cJ ENSMUSG00180004518
 protein coding gene Chr4:7588320-7607440 (-)
C3H/HeJ ENSMUSG00175016475
 protein coding gene Chr4:8108122-8127335 (-)
C57BL/6NJ ENSMUSG00215004397
 protein coding gene Chr4:7732853-7752124 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025802
 protein coding gene Chr4:7026489-7045492 (-)
CAST/EiJ ENSTCUG00005024834
 protein coding gene Chr4:7787589-7807151 (-)
CBA/J ENSMUSG00210002034
 protein coding gene Chr4:7847847-7867059 (-)
DBA/2J ENSMUSG00185002309
 protein coding gene Chr4:7957072-7976287 (-)
FVB/NJ ENSMUSG00205002830
 protein coding gene Chr4:7617735-7636853 (-)
JF1/MsJ ENSUMUG00000001073
 protein coding gene Chr4:8050705-8070139 (-)
LP/J ENSMUSG00230000900
 protein coding gene Chr4:11138024-11157141 (-)
NOD/ShiLtJ ENSMUSG00190012659
 protein coding gene Chr4:7691477-7710553 (-)
NZO/HlLtJ ENSMUSG00225008297
 protein coding gene Chr4:15148885-15168002 (-)
PWK/PhJ ENSLUMG00010005557
 protein coding gene Chr4:7537876-7557305 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005013571
 protein coding gene Chr4:7621346-7640612 (-)



Homology
more
  • Human Ortholog
    PLEKHF2, pleckstrin homology and FYVE domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHF2, pleckstrin homology and FYVE domain containing 2
  • Synonyms
    EAPF, PHAFIN2, ZFYVE18
  • Links
    NCBI Gene ID: 79666
    UniProt: Q9H8W4

  • Chr Location
    8q22.1; chr8:95115642-95156698 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    652
  • Tissues
    34
  • cDNA Data
    55
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71801 NCBI Gene Model | MGI Sequence Detail 18958 C57BL/6J ±  kb
    transcript NM_175175 RefSeq | MGI Sequence Detail 2956 C57BL/6  
    polypeptide Q91WB4 UniProt | EBI | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 55

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2135557
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:391328 Zafeer MF, et al., Distal enhancer-insulator module of GDF6 is essential for cochlear formation. JCI Insight. 2026 Aug 10;11(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory