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Nectin4 Gene Detail
Summary
  • Symbol
    Nectin4
  • Name
    nectin cell adhesion molecule 4
  • Synonyms
    1200017F15Rik, nectin 4, Prr4, Pvrl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918990
    NCBI Gene: 71740
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171197741-171215855 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.37 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    469 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918990
 protein coding gene Chr1:171197667-171216166 (+)
129S1/SvImJ ENSMUSG00200046641
 protein coding gene Chr1:168680279-168698748 (+)
A/J ENSMUSG00195048311
 protein coding gene Chr1:168031318-168049741 (+)
AKR/J ENSMUSG00220026732
 protein coding gene Chr1:167781619-167800099 (+)
BALB/cJ ENSMUSG00180044381
 protein coding gene Chr1:168320538-168339012 (+)
C3H/HeJ ENSMUSG00175041736
 protein coding gene Chr1:168331609-168350082 (+)
C57BL/6NJ ENSMUSG00215044241
 protein coding gene Chr1:168154500-168173146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014869
 protein coding gene Chr1:161635540-161653587 (+)
CAST/EiJ ENSTCUG00005043456
 protein coding gene Chr1:166665139-166683660 (+)
CBA/J ENSMUSG00210034838
 protein coding gene Chr1:168208592-168227020 (+)
DBA/2J ENSMUSG00185027599
 protein coding gene Chr1:172522547-172540965 (+)
FVB/NJ ENSMUSG00205035533
 protein coding gene Chr1:167217565-167236006 (+)
JF1/MsJ ENSUMUG00000006738
 protein coding gene Chr1:171651403-171670020 (+)
LP/J ENSMUSG00230025676
 protein coding gene Chr1:172097667-172115557 (+)
NOD/ShiLtJ ENSMUSG00190032743
 protein coding gene Chr1:168003382-168021861 (+)
NZO/HlLtJ ENSMUSG00225004037
 protein coding gene Chr1:175715130-175732966 (+)
PWK/PhJ ENSLUMG00010029836
 protein coding gene Chr1:166998088-167016513 (+)
SPRET/EiJ ENSMSPG00010045822
 protein coding gene Chr1:170534472-170552554 (+)
WSB/EiJ ENSIUOG00005037583
 protein coding gene Chr1:167417752-167436407 (+)



Homology
more
  • Human Ortholog
    NECTIN4, nectin cell adhesion molecule 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NECTIN4, nectin cell adhesion molecule 4
  • Synonyms
    EDSS1, LNIR, nectin-4, PRR4, PVRL4
  • Links
    NCBI Gene ID: 81607
    UniProt: Q96NY8

  • Chr Location
    1q23.3; chr1:161070988-161090045 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    10
  • Gene trapped
    2
  • Targeted
    1
  • Genomic Mutations
    2 involving Nectin4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    36 strains or lines available
Mice homozygous for one null allele show reduced inflammation in an OVA-induced asthma model. Mice homozygous for another null allele show partial penetrance of preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    56
  • cDNA Data
    24
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71740 NCBI Gene Model | MGI Sequence Detail 18115 C57BL/6J ±  kb
transcript NM_027893 RefSeq | MGI Sequence Detail 3509 C57BL/6  
polypeptide Q8R007 UniProt | EBI | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 25
    Primer pair 3
    Other 2
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory