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Aox3 Gene Detail
Summary
  • Symbol
    Aox3
  • Name
    aldehyde oxidase 3
  • Synonyms
    1200011D03Rik, AOH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918974
    NCBI Gene: 71724
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:58152289-58239857 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 28.96 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    862 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918974
 protein coding gene Chr1:58152289-58241380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016046
 protein coding gene Chr1:57951945-58042399 (+)
A/J MGP_AJ_G0016029
 protein coding gene Chr1:55936678-56025359 (+)
AKR/J MGP_AKRJ_G0015985
 protein coding gene Chr1:57439320-57531664 (+)
BALB/cJ MGP_BALBcJ_G0015984
 protein coding gene Chr1:55967208-56054684 (+)
C3H/HeJ MGP_C3HHeJ_G0015816
 protein coding gene Chr1:57715836-57805342 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016437
 protein coding gene Chr1:60318949-60408371 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014159
 protein coding gene Chr1:51871909-51961211 (+)
CAST/EiJ MGP_CASTEiJ_G0015398
 protein coding gene Chr1:56969055-57056192 (+)
CBA/J MGP_CBAJ_G0015788
 protein coding gene Chr1:62071815-62162993 (+)
DBA/2J MGP_DBA2J_G0015889
 protein coding gene Chr1:55340304-55427433 (+)
FVB/NJ MGP_FVBNJ_G0015891
 protein coding gene Chr1:54675909-54762635 (+)
LP/J MGP_LPJ_G0015961
 protein coding gene Chr1:58840650-58931931 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015911
 protein coding gene Chr1:65085013-65177108 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016484
 protein coding gene Chr1:57425401-57524790 (+)
PWK/PhJ MGP_PWKPhJ_G0015184
 protein coding gene Chr1:54722110-54815635 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014965
 protein coding gene Chr1:57014752-57103023 (+)
WSB/EiJ MGP_WSBEiJ_G0015461
 protein coding gene Chr1:57106195-57191560 (+)



Homology
more
  • Human Ortholog
    AOX3P, aldehyde oxidase 3, pseudogene
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AOX3P, aldehyde oxidase 3, pseudogene
  • Synonyms
    AOH1, AOX3
  • Links
    NCBI Gene ID: 107126360

  • Chr Location
    2q33.1; chr2:200678233-200738781 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    25
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064294 Ensembl Gene Model | MGI Sequence Detail 87569 C57BL/6J ±  kb
transcript ENSMUST00000040999 Ensembl | MGI Sequence Detail 4606 Not Applicable  
polypeptide ENSMUSP00000049391 Ensembl | MGI Sequence Detail 1335 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • PDB
    3ZYV
  • EC
    1.17.3.-, 1.2.3.1
  • InterPro Domains
    IPR002888 [2Fe-2S]-binding
    IPR036884 [2Fe-2S]-binding domain superfamily
    IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
    IPR036010 2Fe-2S ferredoxin-like superfamily
    IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
    IPR014313 Aldehyde oxidase
    IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
    IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
    IPR008274 Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain
    IPR016208 Aldehyde oxidase/xanthine dehydrogenase-like
    IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
    IPR046867 Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain
    IPR012675 Beta-grasp domain superfamily
    IPR005107 CO dehydrogenase flavoprotein, C-terminal
    IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily
    IPR016166 FAD-binding domain, PCMH-type
    IPR036318 FAD-binding, type PCMH-like superfamily
    IPR016167 FAD-binding, type PCMH, subdomain 1
    IPR016169 FAD-binding, type PCMH, subdomain 2
    IPR002346 Molybdopterin dehydrogenase, FAD-binding
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138211
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:327415 Jing J, et al., Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory