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Llgl2 Gene Detail
Summary
  • Symbol
    Llgl2
  • Name
    LLGL2 scribble cell polarity complex component
  • Synonyms
    9130006H11Rik, MGC:27928
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918843
    NCBI Gene: 217325
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115714875-115746606 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1018 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918843
 protein coding gene Chr11:115714855-115746606 (+)
129S1/SvImJ ENSMUSG00200050203
 protein coding gene Chr11:113089672-113113297 (+)
A/J ENSMUSG00195030188
 protein coding gene Chr11:112794525-112818145 (+)
AKR/J ENSMUSG00220027834
 protein coding gene Chr11:112900908-112921899 (+)
BALB/cJ ENSMUSG00180050997
 protein coding gene Chr11:113093537-113114525 (+)
C3H/HeJ ENSMUSG00175039803
 protein coding gene Chr11:113046348-113069969 (+)
C57BL/6NJ ENSMUSG00215044600
 protein coding gene Chr11:112585714-112606700 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017418
 protein coding gene Chr11:111671956-111706204 (+)
CAST/EiJ ENSTCUG00005036413
 protein coding gene Chr11:112449921-112473820 (+)
CBA/J ENSMUSG00210050031
 protein coding gene Chr11:112766334-112789954 (+)
DBA/2J ENSMUSG00185021902
 protein coding gene Chr11:113085102-113106086 (+)
FVB/NJ ENSMUSG00205020164
 protein coding gene Chr11:112888294-112911902 (+)
JF1/MsJ ENSUMUG00000049990
 protein coding gene Chr11:113348328-113371433 (+)
LP/J ENSMUSG00230044012
 protein coding gene Chr11:114139683-114163301 (+)
NOD/ShiLtJ ENSMUSG00190046786
 protein coding gene Chr11:113114129-113137752 (+)
NZO/HlLtJ ENSMUSG00225050258
 protein coding gene Chr11:116192264-116215887 (+)
PWK/PhJ ENSLUMG00010020958
 protein coding gene Chr11:112868441-112891660 (+)
SPRET/EiJ ENSMSPG00010041976
 protein coding gene Chr11:113373925-113408020 (+)
WSB/EiJ ENSIUOG00005039669
 protein coding gene Chr11:112856046-112879265 (+)



Homology
more
  • Human Ortholog
    LLGL2, LLGL scribble cell polarity complex component 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LLGL2, LLGL scribble cell polarity complex component 2
  • Synonyms
    HGL, Hugl-2, LGL2
  • Links
    NCBI Gene ID: 3993
    UniProt: Q6P1M3

  • Chr Location
    17q25.1; chr17:75525002-75575215 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele exhibit abnormal branching morphogenesis of the placental labyrinth layer and are born as runts but catch up in size by adulthood.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    43
  • cDNA Data
    98
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020782 Ensembl Gene Model | MGI Sequence Detail 31732 C57BL/6J ±  kb
    transcript ENSMUST00000177736 Ensembl | MGI Sequence Detail 3612 Not Applicable  
    polypeptide ENSMUSP00000136054 Ensembl | MGI Sequence Detail 1051 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000009848 LLGL scribble cell polarity complex component 2
      (term hierarchy)
    • InterPro Domains
      IPR060769 EIF3B-like, beta-propeller domain superfamily
      IPR000664 Lethal(2) giant larvae protein
      IPR013577 Lethal giant larvae homologue 2, N-terminal domain
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q3TJ91 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 98
      Primer pair 2
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory