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Ibtk Gene Detail
Summary
  • Symbol
    Ibtk
  • Name
    inhibitor of Bruton agammaglobulinemia tyrosine kinase
  • Synonyms
    5430411K16Rik, mKIAA1417
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918677
    NCBI Gene: 108837
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:85569413-85631387 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1938 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918677
 protein coding gene Chr9:85569412-85632756 (-)
129S1/SvImJ ENSMUSG00200005405
 protein coding gene Chr9:82674442-82736472 (-)
A/J ENSMUSG00195007038
 protein coding gene Chr9:82472353-82534333 (-)
AKR/J ENSMUSG00220019464
 protein coding gene Chr9:82599860-82661857 (-)
BALB/cJ ENSMUSG00180006939
 protein coding gene Chr9:82577058-82639048 (-)
C3H/HeJ ENSMUSG00175004632
 protein coding gene Chr9:82637129-82699109 (-)
C57BL/6NJ ENSMUSG00215009653
 protein coding gene Chr9:82575829-82637807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032492
 protein coding gene Chr9:82268343-82333896 (-)
CAST/EiJ ENSTCUG00005003704
 protein coding gene Chr9:82198541-82266333 (-)
CBA/J ENSMUSG00210005426
 protein coding gene Chr9:82694544-82756520 (-)
DBA/2J ENSMUSG00185001717
 protein coding gene Chr9:82705169-82767131 (-)
FVB/NJ ENSMUSG00205004187
 protein coding gene Chr9:82880480-82947212 (-)
JF1/MsJ ENSUMUG00000022000
 protein coding gene Chr9:82580079-82641873 (-)
LP/J ENSMUSG00230006941
 protein coding gene Chr9:82809894-82871934 (-)
NOD/ShiLtJ ENSMUSG00190010980
 protein coding gene Chr9:82764420-82832857 (-)
NZO/HlLtJ ENSMUSG00225015730
 protein coding gene Chr9:83006166-83068128 (-)
PWK/PhJ ENSLUMG00010002722
 protein coding gene Chr9:82528559-82597450 (-)
SPRET/EiJ ENSMSPG00010002260
 protein coding gene Chr9:83957336-84014529 (-)
WSB/EiJ ENSIUOG00005003509
 protein coding gene Chr9:82158889-82227294 (-)



Homology
more
  • Human Ortholog
    IBTK, inhibitor of Bruton tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IBTK, inhibitor of Bruton tyrosine kinase
  • Synonyms
    BTBD26, BTKI
  • Links
    NCBI Gene ID: 25998
    UniProt: Q9P2D0

  • Chr Location
    6q14.1; chr6:82169984-82247775 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit more sustained calcium fluxes in spleen cells stimulated with IgM.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    667
  • Tissues
    39
  • cDNA Data
    14
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035941 Ensembl Gene Model | MGI Sequence Detail 61975 C57BL/6J ±  kb
transcript ENSMUST00000039213 Ensembl | MGI Sequence Detail 5650 Not Applicable  
polypeptide ENSMUSP00000041145 Ensembl | MGI Sequence Detail 1352 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008879 inhibitor of Bruton tyrosine kinase
    (term hierarchy)
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR000210 BTB/POZ domain
    IPR051625 Diverse Signaling and Regulatory Domain-Containing Protein
    IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
    IPR000408 Regulator of chromosome condensation, RCC1
    IPR011333 SKP1/BTB/POZ domain superfamily
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2142931
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory