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Rcbtb1 Gene Detail
Summary
  • Symbol
    Rcbtb1
  • Name
    regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
  • Synonyms
    5430409I18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918580
    NCBI Gene: 71330
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:59438658-59474714 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 31.47 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    724 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918580
 protein coding gene Chr14:59438471-59474716 (+)
129S1/SvImJ ENSMUSG00200040597
 protein coding gene Chr14:48033257-48033399 (+)
129S1/SvImJ ENSMUSGG00200054567
 protein coding gene Chr14:48033767-48041098 (+)
A/J ENSMUSGG00195055078
 protein coding gene Chr14:48251167-48258502 (+)
A/J ENSMUSG00195032354
 protein coding gene Chr14:48250657-48250799 (+)
AKR/J ENSMUSGG00220054460
 protein coding gene Chr14:47584803-47592122 (+)
AKR/J ENSMUSG00220024682
 protein coding gene Chr14:47584293-47584435 (+)
BALB/cJ ENSMUSGG00180055136
 protein coding gene Chr14:47873162-47880497 (+)
BALB/cJ ENSMUSG00180049183
 protein coding gene Chr14:47872652-47872794 (+)
C3H/HeJ ENSMUSGG00175055066
 protein coding gene Chr14:49582104-49589431 (+)
C3H/HeJ ENSMUSG00175045530
 protein coding gene Chr14:49581594-49581736 (+)
C57BL/6NJ ENSMUSG00215048019
 protein coding gene Chr14:47771320-47771462 (+)
C57BL/6NJ ENSMUSGG00215055376
 protein coding gene Chr14:47771830-47779161 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019361
 protein coding gene Chr14:50404976-50442687 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055040
 protein coding gene Chr14:48241398-48248729 (+)
CBA/J ENSMUSG00210044766
 protein coding gene Chr14:48240888-48241030 (+)
DBA/2J ENSMUSG00185029960
 protein coding gene Chr14:53379814-53379956 (+)
DBA/2J ENSMUSGG00185057665
 protein coding gene Chr14:53380324-53387643 (+)
FVB/NJ ENSMUSGG00205054206
 protein coding gene Chr14:47647721-47655060 (+)
FVB/NJ ENSMUSG00205019471
 protein coding gene Chr14:47647211-47647353 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055587
 protein coding gene Chr14:65402738-65410069 (+)
LP/J ENSMUSG00230032329
 protein coding gene Chr14:65402228-65402370 (+)
NOD/ShiLtJ ENSMUSG00190026689
 protein coding gene Chr14:48005190-48005332 (+)
NOD/ShiLtJ ENSMUSGG00190054632
 protein coding gene Chr14:48005700-48013031 (+)
NZO/HlLtJ ENSMUSG00225044066
 protein coding gene Chr14:55702727-55702869 (+)
NZO/HlLtJ ENSMUSGG00225055600
 protein coding gene Chr14:55703237-55710560 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010031462
 protein coding gene Chr14:50975817-51010969 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RCBTB1, RCC1 and BTB domain containing protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RCBTB1, RCC1 and BTB domain containing protein 1
  • Synonyms
    CLLD7, CLLL7, GLP, RDEOA
  • Links
    NCBI Gene ID: 55213
    UniProt: Q8NDN9

  • Chr Location
    13q14.2; chr13:49531944-49586740 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RCBTB1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    42
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    37
  • Targeted
    3
  • Genomic Mutations
    1 involving Rcbtb1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    51 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    30
  • cDNA Data
    76
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035469 Ensembl Gene Model | MGI Sequence Detail 36057 C57BL/6J ±  kb
transcript ENSMUST00000043227 Ensembl | MGI Sequence Detail 3903 Not Applicable  
polypeptide ENSMUSP00000037030 Ensembl | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000013832 RCC1 and BTB domain-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR051625 Diverse Signaling and Regulatory Domain-Containing Protein
    IPR047996 RCC1 and BTB domain-containing protein 1, BTB/POZ domain
    IPR058923 RCC1-like domain
    IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
    IPR000408 Regulator of chromosome condensation, RCC1
    IPR011333 SKP1/BTB/POZ domain superfamily
Molecular
Reagents
less
  • All nucleic 76
    cDNA 76

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145800
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:190636 Wiese CB, et al., A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory