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Gca Gene Detail
Summary
  • Symbol
    Gca
  • Name
    grancalcin
  • Synonyms
    5133401E04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918521
    NCBI Gene: 227960
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:62494671-62524453 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 36.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918521
 protein coding gene Chr2:62494629-62524453 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025773
 protein coding gene Chr2:62364856-62396861 (+)
A/J MGP_AJ_G0025749
 protein coding gene Chr2:59973886-60003483 (+)
AKR/J MGP_AKRJ_G0025719
 protein coding gene Chr2:61576493-61606884 (+)
BALB/cJ MGP_BALBcJ_G0025744
 protein coding gene Chr2:60089217-60118509 (+)
C3H/HeJ MGP_C3HHeJ_G0025505
 protein coding gene Chr2:61686076-61719279 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026191
 protein coding gene Chr2:64199337-64230376 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023595
 protein coding gene Chr2:57488018-57518257 (+)
CAST/EiJ MGP_CASTEiJ_G0024969
 protein coding gene Chr2:61765391-61798550 (+)
CBA/J MGP_CBAJ_G0025485
 protein coding gene Chr2:66629402-66663934 (+)
DBA/2J MGP_DBA2J_G0025616
 protein coding gene Chr2:59553550-59586068 (+)
FVB/NJ MGP_FVBNJ_G0025578
 protein coding gene Chr2:59074269-59105568 (+)
LP/J MGP_LPJ_G0025704
 protein coding gene Chr2:62191378-62221847 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025609
 protein coding gene Chr2:68321073-68355287 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026248
 protein coding gene Chr2:61648912-61681465 (+)
PWK/PhJ MGP_PWKPhJ_G0024710
 protein coding gene Chr2:59421505-59457894 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024517
 protein coding gene Chr2:61795509-61828253 (+)
WSB/EiJ MGP_WSBEiJ_G0025037
 protein coding gene Chr2:61973392-62005446 (+)



Homology
more
  • Human Ortholog
    GCA, grancalcin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCA, grancalcin
  • Synonyms
    GCL
  • Links
    NCBI Gene ID: 25801
    neXtProt AC: NX_P28676
    UniProt: P28676

  • Chr Location
    2q24.2; chr2:162318763-162375396 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    6
  • Gene trapped
    3
  • Targeted
    1
  • Genomic Mutations
    1 involving Gca
  • Find Mice (IMSR)
    16 strains or lines available
Mice homozygous for disruptions in this gene are essentially normal. However they do demonstrate an increased resistance to endotoxic shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    2
  • cDNA Data
    15
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 227960 NCBI Gene Model | MGI Sequence Detail 29783 C57BL/6J ±  kb
transcript NM_145523 RefSeq | MGI Sequence Detail 3288 C57BL/6  
polypeptide Q8VC88 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139004
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory