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Poc1b Gene Detail
Summary
  • Symbol
    Poc1b
  • Name
    POC1 centriolar protein B
  • Synonyms
    4933430F16Rik, Wdr51b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918511
    NCBI Gene: 382406
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:98942918-99033936 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 51.06 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    344 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918511
 protein coding gene Chr10:98942898-99033936 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017683
 protein coding gene Chr10:100912842-101010933 (+)
A/J MGP_AJ_G0017662
 protein coding gene Chr10:97271493-97363428 (+)
AKR/J MGP_AKRJ_G0017622
 protein coding gene Chr10:100059590-100159893 (+)
BALB/cJ MGP_BALBcJ_G0017626
 protein coding gene Chr10:97543154-97643183 (+)
C3H/HeJ MGP_C3HHeJ_G0017449
 protein coding gene Chr10:100075875-100170916 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018082
 protein coding gene Chr10:104392935-104491929 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015763
 protein coding gene Chr10:92700486-92800191 (+)
CAST/EiJ MGP_CASTEiJ_G0017012
 protein coding gene Chr10:100140889-100256101 (+)
CBA/J MGP_CBAJ_G0017418
 protein coding gene Chr10:108489707-108590467 (+)
DBA/2J MGP_DBA2J_G0017524
 protein coding gene Chr10:96354443-96445985 (+)
FVB/NJ MGP_FVBNJ_G0017517
 protein coding gene Chr10:95569059-95661702 (+)
LP/J MGP_LPJ_G0017598
 protein coding gene Chr10:101491920-101599913 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017547
 protein coding gene Chr10:109762807-109862762 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018120
 protein coding gene Chr10:99962842-100060409 (+)
PWK/PhJ MGP_PWKPhJ_G0016794
 protein coding gene Chr10:96485075-96581415 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016583
 protein coding gene Chr10:98874301-98978268 (+)
WSB/EiJ MGP_WSBEiJ_G0017072
 protein coding gene Chr10:99973043-100072413 (+)



Homology
more
  • Human Ortholog
    POC1B, POC1 centriolar protein B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POC1B, POC1 centriolar protein B
  • Synonyms
    CORD20, PIX1, TUWD12, WDR51B
  • Links
    NCBI Gene ID: 282809
    neXtProt AC: NX_Q8TC44
    UniProt: Q8TC44

  • Chr Location
    12q21.33; chr12:89419718-89526047 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Poc1b mouse models; 1 with human POC1B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    5
  • cDNA Data
    51
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382406 NCBI Gene Model | MGI Sequence Detail 91019 C57BL/6J ±  kb
    transcript NR_153333 RefSeq | MGI Sequence Detail 2935 Not Specified  
    polypeptide Q8BHD1 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 2
      cDNA 51

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:340269 Hua J, et al., Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice. Hum Mol Genet. 2023 Jul 4;32(14):2307-2317
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory