Cfap251 MGI Mouse Gene Detail - MGI:1918495 - cilia and flagella associated protein 251

Symbol

Cfap251
Name

cilia and flagella associated protein 251
Synonyms

4930415N18Rik, 4933428F06Rik, Wdr66

Feature Type

protein coding gene
IDs

MGI:1918495
NCBI Gene: 269701
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:123390196-123465547 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.86 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

2106 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918495	protein coding gene	Chr5:123390165-123465547 (+)
129S1/SvImJ	ENSMUSG00200022999	protein coding gene	Chr5:117115167-117186745 (+)
A/J	ENSMUSG00195011614	protein coding gene	Chr5:116636601-116708176 (+)
AKR/J	ENSMUSG00220034870	protein coding gene	Chr5:116148352-116222093 (+)
BALB/cJ	ENSMUSG00180030612	protein coding gene	Chr5:116751566-116823133 (+)
C3H/HeJ	ENSMUSG00175028479	protein coding gene	Chr5:118768187-118841928 (+)
C57BL/6NJ	ENSMUSG00215023512	protein coding gene	Chr5:116800133-116873839 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027723	protein coding gene	Chr5:116248388-116325255 (+)
CAST/EiJ	ENSTCUG00005039681	protein coding gene	Chr5:116055987-116127625 (+)
CBA/J	ENSMUSG00210009095	protein coding gene	Chr5:117518945-117592667 (+)
DBA/2J	ENSMUSG00185051884	protein coding gene	Chr5:120570211-120643938 (+)
FVB/NJ	ENSMUSG00205033839	protein coding gene	Chr5:116429962-116503658 (+)
JF1/MsJ	ENSUMUG00000013558	protein coding gene	Chr5:123421784-123495276 (+)
LP/J	ENSMUSG00230042116	protein coding gene	Chr5:124637164-124708728 (+)
NOD/ShiLtJ	ENSMUSG00190034973	protein coding gene	Chr5:116444616-116518355 (+)
NZO/HlLtJ	ENSMUSG00225012820	protein coding gene	Chr5:132333050-132406752 (+)
PWK/PhJ	ENSLUMG00010039212	protein coding gene	Chr5:115324142-115397511 (+)
SPRET/EiJ	ENSMSPG00010041468	protein coding gene	Chr5:118620988-118702246 (+)
WSB/EiJ	ENSIUOG00005014121	protein coding gene	Chr5:119132622-119206410 (+)

Human Ortholog

CFAP251, cilia and flagella associated protein 251

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CFAP251, cilia and flagella associated protein 251
Synonyms

CaM-IP4, SPGF33, WDR66
Links

HGNC:28506

NCBI Gene ID: 144406

UniProt: Q8TBY9
Chr Location

12q24.31; chr12:121918574-122003927 (+) GRCh38

MGI Vertebrate Homology

Cfap251 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CFAP251
Gene Tree

Cfap251

Diseases

1 with human CFAP251 associations

				Human Disease	Mouse Models
				spermatogenic failure 33 IDs spermatogenic failure 33 DOID:0111915 OMIM:618152

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cfap251
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

70 strains or lines available

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All GO Annotations

13
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

626
Tissues

13
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cfap251

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All Sequences

47
RefSeq

4
UniProt

5
CCDS

CCDS89985.1

Ensembl

ENSMUSG00000029442 (Evidence)
NCBI Gene

269701

			Length	Strain/Species	Flank
genomic	269701	NCBI Gene Model \| MGI Sequence Detail	75352	C57BL/6J	± kb
transcript	NM_001370840	RefSeq \| MGI Sequence Detail	4771	C57BL/6
polypeptide	E9Q743	UniProt \| EBI \| MGI Sequence Detail	1299	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029865 cilia- and flagella-associated protein 251

(term hierarchy)
PDB

9D2F
InterPro Domains

IPR063632 CFAP251, C-terminal domain

IPR011992 EF-hand domain pair

IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily

IPR011044 Quinoprotein amine dehydrogenase, beta chain-like

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR050630 WD repeat Echinoderm Microtubule-associated Protein-like
GlyGen

E9Q743 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 7

Genomic 1

cDNA 6

Microarray probesets 5

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MGI:1924119, MGI:7414083

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cfap251:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48777	Chr5:123390150-123390199 (+)	-21 bp
Tssr48778	Chr5:123391729-123391755 (+)	1,546 bp
Tssr48779	Chr5:123411811-123411814 (+)	21,617 bp
Tssr48780	Chr5:123440465-123440474 (+)	50,274 bp
Tssr48781	Chr5:123440476-123440489 (+)	50,287 bp
Tssr48782	Chr5:123440560-123440571 (+)	50,370 bp
Tssr48783	Chr5:123448562-123448585 (+)	58,378 bp
Tssr48784	Chr5:123448596-123448607 (+)	58,406 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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