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Rbbp5 Gene Detail
Summary
  • Symbol
    Rbbp5
  • Name
    retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit
  • Synonyms
    4933411J24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918367
    NCBI Gene: 213464
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132405103-132433397 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918367
 protein coding gene Chr1:132405087-132436382 (+)
129S1/SvImJ ENSMUSG00200007910
 protein coding gene Chr1:129968763-129996852 (+)
A/J ENSMUSG00195042101
 protein coding gene Chr1:129072052-129100238 (+)
AKR/J ENSMUSG00220046636
 protein coding gene Chr1:128899994-128928083 (+)
BALB/cJ ENSMUSG00180031246
 protein coding gene Chr1:129618192-129646395 (+)
C3H/HeJ ENSMUSG00175037605
 protein coding gene Chr1:129316578-129344764 (+)
C57BL/6NJ ENSMUSG00215043506
 protein coding gene Chr1:129330194-129358488 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014588
 protein coding gene Chr1:124067842-124097627 (+)
CAST/EiJ ENSTCUG00005033017
 protein coding gene Chr1:128236418-128264459 (+)
CBA/J ENSMUSG00210025304
 protein coding gene Chr1:129212960-129241157 (+)
DBA/2J ENSMUSG00185030672
 protein coding gene Chr1:133567543-133595626 (+)
FVB/NJ ENSMUSG00205035448
 protein coding gene Chr1:128549373-128577577 (+)
JF1/MsJ ENSUMUG00000020381
 protein coding gene Chr1:132734256-132762312 (+)
LP/J ENSMUSG00230035996
 protein coding gene Chr1:133155212-133183506 (+)
NOD/ShiLtJ ENSMUSG00190042138
 protein coding gene Chr1:129226571-129254759 (+)
NZO/HlLtJ ENSMUSG00225016535
 protein coding gene Chr1:136875445-136905617 (+)
PWK/PhJ ENSLUMG00010025956
 protein coding gene Chr1:128343644-128371771 (+)
SPRET/EiJ ENSMSPG00010044875
 protein coding gene Chr1:131150479-131178423 (+)
WSB/EiJ ENSIUOG00005043369
 protein coding gene Chr1:128961438-128989691 (+)



Homology
more
  • Human Ortholog
    RBBP5, RB binding protein 5, histone lysine methyltransferase complex subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBBP5, RB binding protein 5, histone lysine methyltransferase complex subunit
  • Synonyms
    RBQ3, SWD1
  • Links
    NCBI Gene ID: 5929
    UniProt: Q15291

  • Chr Location
    1q32.1; chr1:205086142-205122015 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    17
  • cDNA Data
    15
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026439 Ensembl Gene Model | MGI Sequence Detail 28295 C57BL/6J ±  kb
transcript ENSMUST00000190997 Ensembl | MGI Sequence Detail 2856 Not Applicable  
polypeptide ENSMUSP00000141003 Ensembl | MGI Sequence Detail 538 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15
    Antibodies 2

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 4
    Gene Ontology 16
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:360830 Kubra S, et al., The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasis. bioRxiv. 2024 Sep 13;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory