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Gpr39 Gene Detail
Summary
  • Symbol
    Gpr39
  • Name
    G protein-coupled receptor 39
  • Synonyms
    4933415E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918361
    NCBI Gene: 71111
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:125604732-125801599 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 54.70 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2602 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918361
 protein coding gene Chr1:125604725-125804132 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016416
 protein coding gene Chr1:128774543-128986523 (+)
A/J MGP_AJ_G0016399
 protein coding gene Chr1:124040083-124239441 (+)
AKR/J MGP_AKRJ_G0016364
 protein coding gene Chr1:127667063-127868252 (+)
BALB/cJ MGP_BALBcJ_G0016359
 protein coding gene Chr1:124390284-124596299 (+)
C3H/HeJ MGP_C3HHeJ_G0016185
 protein coding gene Chr1:127865611-128072824 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016820
 protein coding gene Chr1:133645244-133858373 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014533
 protein coding gene Chr1:117438605-117641947 (+)
CAST/EiJ MGP_CASTEiJ_G0015766
 protein coding gene Chr1:126779256-126994518 (+)
CBA/J MGP_CBAJ_G0016158
 protein coding gene Chr1:138144969-138350411 (+)
DBA/2J MGP_DBA2J_G0016264
 protein coding gene Chr1:123042078-123243359 (+)
FVB/NJ MGP_FVBNJ_G0016263
 protein coding gene Chr1:121783025-121984866 (+)
LP/J MGP_LPJ_G0016335
 protein coding gene Chr1:130117685-130329028 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016288
 protein coding gene Chr1:144094917-144314463 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016856
 protein coding gene Chr1:127438111-127644865 (+)
PWK/PhJ MGP_PWKPhJ_G0015552
 protein coding gene Chr1:122018757-122221215 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015340
 protein coding gene Chr1:126365264-126588650 (+)
WSB/EiJ MGP_WSBEiJ_G0015828
 protein coding gene Chr1:127387233-127597204 (+)



Homology
more
  • Human Ortholog
    GPR39, G protein-coupled receptor 39
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR39, G protein-coupled receptor 39
  • Synonyms
    ZnR
  • Links
    NCBI Gene ID: 2863
    neXtProt AC: NX_O43194
    UniProt: O43194

  • Chr Location
    2q21.2; chr2:132416805-132646582 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal glucose homeostasis when fed a high sugar diet. Mice homozygous for a different null allele have accelerated gastric emptying, decreased fasting-induced hyperphagia, and increasedbody weight after oneyear of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026343 Ensembl Gene Model | MGI Sequence Detail 196868 C57BL/6J ±  kb
    transcript ENSMUST00000027581 Ensembl | MGI Sequence Detail 2691 Not Applicable  
    polypeptide ENSMUSP00000027581 Ensembl | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 52
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:343735 Zhang L, et al., Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles. Biochem Pharmacol. 2023 Dec 2;219:115961
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory