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Mterf4 Gene Detail
Summary
  • Symbol
    Mterf4
  • Name
    mitochondrial transcription termination factor 4
  • Synonyms
    1810059A23Rik, 4933412H03Rik, Mterfd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918355
    NCBI Gene: 69821
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93228927-93233601 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.24 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918355
 protein coding gene Chr1:93226933-93233637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016338
 protein coding gene Chr1:94917220-94923924 (-)
A/J MGP_AJ_G0016319
 protein coding gene Chr1:91517149-91523851 (-)
AKR/J MGP_AKRJ_G0016280
 protein coding gene Chr1:94217991-94224693 (-)
BALB/cJ MGP_BALBcJ_G0016275
 protein coding gene Chr1:91698704-91705406 (-)
C3H/HeJ MGP_C3HHeJ_G0016104
 protein coding gene Chr1:94472563-94479269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016734
 protein coding gene Chr1:98529693-98536397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014452
 protein coding gene Chr1:85766048-85772697 (-)
CAST/EiJ MGP_CASTEiJ_G0015687
 protein coding gene Chr1:93801985-93808683 (-)
CBA/J MGP_CBAJ_G0016078
 protein coding gene Chr1:101720383-101727075 (-)
DBA/2J MGP_DBA2J_G0016183
 protein coding gene Chr1:90712461-90719163 (-)
FVB/NJ MGP_FVBNJ_G0016182
 protein coding gene Chr1:89786966-89793668 (-)
LP/J MGP_LPJ_G0016254
 protein coding gene Chr1:96096081-96102785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016207
 protein coding gene Chr1:104829413-104836115 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016773
 protein coding gene Chr1:94234912-94241620 (-)
PWK/PhJ MGP_PWKPhJ_G0015472
 protein coding gene Chr1:90150392-90157089 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015256
 protein coding gene Chr1:93186103-93192797 (-)
WSB/EiJ MGP_WSBEiJ_G0015747
 protein coding gene Chr1:94053870-94060570 (-)



Homology
more
  • Human Ortholog
    MTERF4, mitochondrial transcription termination factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTERF4, mitochondrial transcription termination factor 4
  • Synonyms
    MTERFD2
  • Links
    NCBI Gene ID: 130916
    neXtProt AC: NX_Q7Z6M4
    UniProt: Q7Z6M4

  • Chr Location
    2q37.3; chr2:241042586-241102332 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with decreased embryo size, lack of heart, and absence of optic discs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    45
  • cDNA Data
    43
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69821 NCBI Gene Model | MGI Sequence Detail 4675 C57BL/6J ±  kb
    transcript NM_178051 RefSeq | MGI Sequence Detail 1330 C57BL/6  
    polypeptide Q8BVN4 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030235 transcription termination factor 4, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR038538 MTERF superfamily, mitochondrial/chloroplastic
      IPR003690 Transcription termination factor, mitochondrial/chloroplastic
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 43
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917071
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:275484 Castillo A, et al., Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1298-1312
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory