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Agbl4 Gene Detail
Summary
  • Symbol
    Agbl4
  • Name
    ATP/GTP binding protein-like 4
  • Synonyms
    4930578N11Rik, 4931433A01Rik, Ccp6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918244
    NCBI Gene: 78933
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:110254858-111514707 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 51.43 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27791 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918244
 protein coding gene Chr4:110254823-111521521 (+)
129S1/SvImJ ENSMUSG00200048433
 protein coding gene Chr4:105299277-106589891 (+)
A/J ENSMUSG00195041618
 protein coding gene Chr4:105849592-107126380 (+)
AKR/J ENSMUSG00220011145
 protein coding gene Chr4:105205514-106451591 (+)
BALB/cJ ENSMUSG00180044248
 protein coding gene Chr4:104678902-105947662 (+)
C3H/HeJ ENSMUSG00175032726
 protein coding gene Chr4:105683087-106962135 (+)
C57BL/6NJ ENSMUSG00215019960
 protein coding gene Chr4:105588694-106890083 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026290
 protein coding gene Chr4:102475419-103607893 (+)
CAST/EiJ ENSTCUG00005021056
 protein coding gene Chr4:104766597-105954426 (+)
CBA/J ENSMUSG00210053044
 protein coding gene Chr4:105316148-106575756 (+)
DBA/2J ENSMUSG00185048600
 protein coding gene Chr4:106015409-107286855 (+)
FVB/NJ ENSMUSG00205035560
 protein coding gene Chr4:104258706-105440730 (+)
JF1/MsJ ENSUMUG00000034316
 protein coding gene Chr4:106022553-107243653 (+)
LP/J ENSMUSG00230005735
 protein coding gene Chr4:109335494-110606901 (+)
NOD/ShiLtJ ENSMUSG00190027253
 protein coding gene Chr4:104685926-105945260 (+)
NZO/HlLtJ ENSMUSG00225010941
 protein coding gene Chr4:114438347-115707265 (+)
PWK/PhJ ENSLUMG00010039786
 protein coding gene Chr4:103731595-104959214 (+)
SPRET/EiJ ENSMSPG00010025054
 protein coding gene Chr4:106000072-107206976 (+)
WSB/EiJ ENSIUOG00005035554
 protein coding gene Chr4:104870270-106180862 (+)



Homology
more
  • Human Ortholog
    AGBL4, AGBL carboxypeptidase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGBL4, AGBL carboxypeptidase 4
  • Synonyms
    CCP6
  • Links
    NCBI Gene ID: 84871
    UniProt: Q5VU57

  • Chr Location
    1p33; chr1:48522511-50023954 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal platelet morphology and physiology, impaired megakaryopoiesis, increased spleen weight and increased susceptibility to HSV or VACV infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    659
  • Tissues
    11
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061298 Ensembl Gene Model | MGI Sequence Detail 1259850 C57BL/6J ±  kb
    transcript ENSMUST00000097920 Ensembl | MGI Sequence Detail 1798 Not Applicable  
    polypeptide ENSMUSP00000095533 Ensembl | MGI Sequence Detail 540 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1926183
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 14
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:370214 Gavoci A, et al., Polyglutamylation of microtubules drives neuronal remodeling. Nat Commun. 2025 Jun 25;16(1):5384
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory