Trim69 MGI Mouse Gene Detail - MGI:1918178 - tripartite motif-containing 69

Symbol

Trim69
Name

tripartite motif-containing 69
Synonyms

4921519C19Rik, Rnf36, Trif

Feature Type

protein coding gene
IDs

MGI:1918178
NCBI Gene: 70928
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:121991189-122009503 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.55 cM
Mapping Data

1 experiment

SNPs within 2kb

547 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918178	protein coding gene	Chr2:121991181-122009508 (+)
129S1/SvImJ	ENSMUSG00200045180	protein coding gene	Chr2:118922512-118942657 (+)
A/J	ENSMUSG00195024877	protein coding gene	Chr2:118961616-118981109 (+)
AKR/J	ENSMUSG00220039673	protein coding gene	Chr2:118884923-118905022 (+)
BALB/cJ	ENSMUSG00180040244	protein coding gene	Chr2:118762363-118781854 (+)
C3H/HeJ	ENSMUSG00175024333	protein coding gene	Chr2:119236268-119255759 (+)
C57BL/6NJ	ENSMUSG00215020837	protein coding gene	Chr2:118910018-118928352 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024207	protein coding gene	Chr2:115004375-115025542 (+)
CAST/EiJ	ENSTCUG00005015997	protein coding gene	Chr2:118178009-118196417 (+)
CBA/J	ENSMUSG00210007139	protein coding gene	Chr2:119077121-119096612 (+)
DBA/2J	ENSMUSG00185041850	protein coding gene	Chr2:118759503-118778994 (+)
FVB/NJ	ENSMUSG00205031549	protein coding gene	Chr2:117985277-118005378 (+)
JF1/MsJ	ENSUMUG00000007864	protein coding gene	Chr2:118658269-118676595 (+)
LP/J	ENSMUSG00230019686	protein coding gene	Chr2:120581944-120603677 (+)
NOD/ShiLtJ	ENSMUSG00190029823	protein coding gene	Chr2:119009427-119029525 (+)
NZO/HlLtJ	ENSMUSG00225003036	protein coding gene	Chr2:128483748-128503239 (+)
PWK/PhJ	ENSLUMG00010039611	protein coding gene	Chr2:118595039-118613621 (+)
SPRET/EiJ	ENSMSPG00010036105	protein coding gene	Chr2:120989139-121013445 (+)
WSB/EiJ	ENSIUOG00005024454	protein coding gene	Chr2:118732727-118752830 (+)

Human Ortholog

TRIM69, tripartite motif containing 69

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM69, tripartite motif containing 69
Synonyms

HSD-34, HSD34, RNF36, Trif
Links

HGNC:17857

NCBI Gene ID: 140691

UniProt: Q86WT6
Chr Location

15q21.1; chr15:44728988-44767829 (+) GRCh38

MGI Vertebrate Homology

Trim69 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRIM69
Gene Tree

Trim69

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Trim69
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

Mice homozygous for a knock-out allele are viable and exhibit normal body development, fertility and behavior. Male mice show normal spermatogenesis with no detectable alterations in sperm morphology, count or motility.

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All GO Annotations

37
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

649
Tissues

31
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim69, trim69.2

ZFIN trim69

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All Sequences

37
RefSeq

6
UniProt

2
CCDS

CCDS16655.1

Ensembl

ENSMUSG00000033368 (Evidence)
NCBI Gene

70928

			Length	Strain/Species	Flank
genomic	70928	NCBI Gene Model \| MGI Sequence Detail	18315	C57BL/6J	± kb
transcript	NR_166637	RefSeq \| MGI Sequence Detail	1753	C57BL/6
polypeptide	Q80X56	UniProt \| EBI \| MGI Sequence Detail	500	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016665 E3 ubiquitin-protein ligase TRIM69

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR003879 Butyrophylin-like, SPRY domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR006574 SPRY-associated

IPR003877 SPRY domain

IPR050143 Tripartite motif-containing

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trim69:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19830	Chr2:121991164-121991174 (+)	-20 bp
Tssr626	Chr2:121991177-121991178 (+)	-11 bp
Tssr19831	Chr2:121991182-121991218 (+)	11 bp
Tssr19832	Chr2:121992023-121992040 (+)	843 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24