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Hmgxb4 Gene Detail
Summary
  • Symbol
    Hmgxb4
  • Name
    HMG box domain containing 4
  • Synonyms
    4733401K04Rik, Hmgb2l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918073
    NCBI Gene: 70823
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75720305-75758606 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.57 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    726 from dbSNP Build 142
  • Strain Annotations
    39
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918073
 protein coding gene Chr8:75719984-75758606 (+)
129S1/SvImJ ENSMUSGG00200054896
 protein coding gene Chr8:70063614-70064892 (+)
129S1/SvImJ ENSMUSG00200026440
 protein coding gene Chr8:70065429-70065657 (+)
129S1/SvImJ ENSMUSGG00200054538
 protein coding gene Chr8:70080973-70096652 (+)
A/J ENSMUSG00195014835
 protein coding gene Chr8:70440108-70440336 (+)
A/J ENSMUSGG00195055382
 protein coding gene Chr8:70455684-70471375 (+)
A/J ENSMUSGG00195055050
 protein coding gene Chr8:70438293-70439571 (+)
AKR/J ENSMUSGG00220054804
 protein coding gene Chr8:70554157-70555435 (+)
AKR/J ENSMUSG00220021407
 protein coding gene Chr8:70555972-70556200 (+)
AKR/J ENSMUSGG00220054371
 protein coding gene Chr8:70571542-70587217 (+)
BALB/cJ ENSMUSG00180027437
 protein coding gene Chr8:70273161-70273389 (+)
BALB/cJ ENSMUSGG00180055087
 protein coding gene Chr8:70271346-70272624 (+)
BALB/cJ ENSMUSGG00180055086
 protein coding gene Chr8:70288703-70304391 (+)
C3H/HeJ ENSMUSG00175020602
 protein coding gene Chr8:70367495-70367723 (+)
C3H/HeJ ENSMUSGG00175055002
 protein coding gene Chr8:70383044-70398723 (+)
C3H/HeJ ENSMUSGG00175054867
 protein coding gene Chr8:70365680-70366958 (+)
C57BL/6NJ ENSMUSGG00215055349
 protein coding gene Chr8:69999049-70000327 (+)
C57BL/6NJ ENSMUSGG00215055722
 protein coding gene Chr8:70016442-70032133 (+)
C57BL/6NJ ENSMUSG00215033317
 protein coding gene Chr8:70000864-70001092 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031230
 protein coding gene Chr8:66746318-66787244 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054555
 protein coding gene Chr8:70305023-70320706 (+)
CBA/J ENSMUSG00210027424
 protein coding gene Chr8:70289475-70289703 (+)
CBA/J ENSMUSGG00210054738
 protein coding gene Chr8:70287660-70288938 (+)
DBA/2J ENSMUSGG00185057908
 protein coding gene Chr8:76452049-76453327 (+)
DBA/2J ENSMUSGG00185057566
 protein coding gene Chr8:76469411-76485098 (+)
DBA/2J ENSMUSG00185011732
 protein coding gene Chr8:76453864-76454092 (+)
FVB/NJ ENSMUSGG00205054216
 protein coding gene Chr8:69485479-69501185 (+)
FVB/NJ ENSMUSGG00205054198
 protein coding gene Chr8:69468051-69469329 (+)
FVB/NJ ENSMUSG00205032268
 protein coding gene Chr8:69469866-69470094 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230029914
 protein coding gene Chr8:80116338-80116566 (+)
LP/J ENSMUSGG00230055790
 protein coding gene Chr8:80131901-80147576 (+)
LP/J ENSMUSGG00230055511
 protein coding gene Chr8:80114523-80115801 (+)
NOD/ShiLtJ ENSMUSGG00190054684
 protein coding gene Chr8:70337067-70338345 (+)
NOD/ShiLtJ ENSMUSGG00190055052
 protein coding gene Chr8:70354444-70370119 (+)
NOD/ShiLtJ ENSMUSG00190025368
 protein coding gene Chr8:70338882-70339110 (+)
NZO/HlLtJ ENSMUSG00225023062
 protein coding gene Chr8:83457487-83457715 (+)
NZO/HlLtJ ENSMUSGG00225055495
 protein coding gene Chr8:83473032-83488711 (+)
NZO/HlLtJ ENSMUSGG00225055494
 protein coding gene Chr8:83455672-83456950 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010022885
 protein coding gene Chr8:71997886-72034145 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HMGXB4, HMG-box containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGXB4, HMG-box containing 4
  • Synonyms
    HMG2L1, HMGBCG, P53N, THC211630
  • Links
    NCBI Gene ID: 10042
    UniProt: Q9UGU5

  • Chr Location
    22q12.3; chr22:35241536-35295807 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are protected against LPS-induced acute lung injury and against septic shock-induced lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    702
  • Tissues
    78
  • cDNA Data
    101
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70823 NCBI Gene Model | MGI Sequence Detail 38302 C57BL/6J ±  kb
    transcript NM_001316753 RefSeq | MGI Sequence Detail 3991 C57BL/6  
    polypeptide NP_821136 RefSeq | MGI Sequence Detail 594 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR025228 Domain of unknown function DUF4171
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR042477 HMG domain-containing protein 4
      IPR048016 HMG domain-containing protein 4, HMG-box
    • GlyGen
      Q80Y32 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 1
      cDNA 101
      Primer pair 3
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142500
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347593 Wang L, et al., A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo. Physiol Rep. 2024 Apr;12(8):e16014
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory