About   Help   FAQ
Rprd1b Gene Detail
Summary
  • Symbol
    Rprd1b
  • Name
    regulation of nuclear pre-mRNA domain containing 1B
  • Synonyms
    2610304G08Rik, 2810446G03Rik, Crept
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917720
    NCBI Gene: 70470
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157870395-157920127 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.72 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    303 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917720
protein coding gene Chr2:157870395-157974217 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026788
protein coding gene Chr2:163074654-163187858 (+)
A/J MGP_AJ_G0026754
protein coding gene Chr2:156543147-156651393 (+)
AKR/J MGP_AKRJ_G0026725
protein coding gene Chr2:161164652-161271618 (+)
BALB/cJ MGP_BALBcJ_G0026763
protein coding gene Chr2:156847771-156953160 (+)
C3H/HeJ MGP_C3HHeJ_G0026505
protein coding gene Chr2:161470821-161580724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027212
protein coding gene Chr2:167923006-168044767 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024582
protein coding gene Chr2:149988418-150094863 (+)
CAST/EiJ MGP_CASTEiJ_G0025967
protein coding gene Chr2:161828095-161938575 (+)
CBA/J MGP_CBAJ_G0026482
protein coding gene Chr2:173956739-174079323 (+)
DBA/2J MGP_DBA2J_G0026620
protein coding gene Chr2:155719146-155824354 (+)
FVB/NJ MGP_FVBNJ_G0026587
protein coding gene Chr2:154119641-154227216 (+)
LP/J MGP_LPJ_G0026723
protein coding gene Chr2:163158814-163273509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026608
protein coding gene Chr2:177778327-177891238 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027268
protein coding gene Chr2:160970706-161084806 (+)
PWK/PhJ MGP_PWKPhJ_G0025701
protein coding gene Chr2:155236719-155342836 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025504
protein coding gene Chr2:159899301-160011719 (+)
WSB/EiJ MGP_WSBEiJ_G0026037
protein coding gene Chr2:161878085-161987457 (+)



Homology
more
  • Human Ortholog
    RPRD1B, regulation of nuclear pre-mRNA domain containing 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPRD1B, regulation of nuclear pre-mRNA domain containing 1B
  • Synonyms
    C20orf77, CREPT, dJ1057B20.2, K-H, Kub5-Hera, NET60
  • Links
    NCBI Gene ID: 58490
    neXtProt AC: NX_Q9NQG5
    UniProt: Q9NQG5

  • Chr Location
    20q11.23; chr20:38033725-38127780 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in intestinal cells exhibit increased prenatal mortality, small body size, enlarged and thickened large intestine crypts, impaired proliferation and differentiation of Lgr5+ stem cells, and increased DSS-induced mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70470 NCBI Gene Model | MGI Sequence Detail 49733 C57BL/6J ±  kb
    transcript NM_001291135 RefSeq | MGI Sequence Detail 4616 C57BL/6  
    polypeptide Q9CSU0 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 78
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920005
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:300857 Yang L, et al., CREPT is required for murine stem cell maintenance during intestinal regeneration. Nat Commun. 2021 Jan 11;12(1):270

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory