Rufy2 MGI Mouse Gene Detail - MGI:1917682 - RUN and FYVE domain-containing 2

Symbol

Rufy2
Name

RUN and FYVE domain-containing 2
Synonyms

2610111M19Rik, Denn, LZ-FYVE, ZFYVE13

Feature Type

protein coding gene
IDs

MGI:1917682
NCBI Gene: 70432
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:62816002-62852989 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.51 cM, cytoband B4
Mapping Data

4 experiments

SNPs within 2kb

983 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917682	protein coding gene	Chr10:62815947-62852989 (+)
129S1/SvImJ	ENSMUSG00200026923	protein coding gene	Chr10:59488773-59531950 (+)
A/J	ENSMUSG00195026377	protein coding gene	Chr10:59796108-59839277 (+)
AKR/J	ENSMUSG00220036580	protein coding gene	Chr10:59489415-59532603 (+)
BALB/cJ	ENSMUSG00180025785	protein coding gene	Chr10:59838425-59881592 (+)
C3H/HeJ	ENSMUSG00175023181	protein coding gene	Chr10:59695959-59739120 (+)
C57BL/6NJ	ENSMUSG00215022188	protein coding gene	Chr10:59436522-59479698 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015395	protein coding gene	Chr10:57473233-57510675 (+)
CAST/EiJ	ENSTCUG00005026994	protein coding gene	Chr10:59487976-59524456 (+)
CBA/J	ENSMUSG00210033388	protein coding gene	Chr10:59574225-59617410 (+)
DBA/2J	ENSMUSG00185039272	protein coding gene	Chr10:59915817-59958992 (+)
FVB/NJ	ENSMUSG00205028951	protein coding gene	Chr10:59587921-59631074 (+)
JF1/MsJ	ENSUMUG00000017159	protein coding gene	Chr10:61158470-61200231 (+)
LP/J	ENSMUSG00230014312	protein coding gene	Chr10:61718707-61761858 (+)
NOD/ShiLtJ	ENSMUSG00190026991	protein coding gene	Chr10:59901465-59944614 (+)
NZO/HlLtJ	ENSMUSG00225043382	protein coding gene	Chr10:65999757-66042908 (+)
PWK/PhJ	ENSLUMG00010021474	protein coding gene	Chr10:59545196-59586919 (+)
SPRET/EiJ	ENSMSPG00010021290	protein coding gene	Chr10:61098462-61131578 (+)
WSB/EiJ	ENSIUOG00005040503	protein coding gene	Chr10:59482025-59525062 (+)

Human Ortholog

RUFY2, RUN and FYVE domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RUFY2, RUN and FYVE domain containing 2
Synonyms

RABIP4R, ZFYVE13
Links

HGNC:19761

NCBI Gene ID: 55680

UniProt: Q8WXA3
Chr Location

10q21.3; chr10:68341107-68407313 (-) GRCh38

MGI Vertebrate Homology

Rufy2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RUFY2
Gene Tree

Rufy2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Rufy2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

681
Tissues

66
cDNA Data

21
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rufy2

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All Sequences

84
RefSeq

16
UniProt

10
CCDS

CCDS48582.1

Ensembl

ENSMUSG00000020070 (Evidence)
NCBI Gene

70432

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020070	Ensembl Gene Model \| MGI Sequence Detail	36988	C57BL/6J	± kb
transcript	ENSMUST00000119567	Ensembl \| MGI Sequence Detail	4130	Not Applicable
polypeptide	ENSMUSP00000113429	Ensembl \| MGI Sequence Detail	606	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000031903 RUN and FYVE domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR000306 FYVE zinc finger

IPR047335 RUN and FYVE domain-containing protein 1-3

IPR047333 RUN and FYVE domain-containing protein 2, FYVE domain

IPR047332 RUN and FYVE domain-containing protein 2, RUN domain

IPR004012 RUN domain

IPR037213 RUN domain superfamily

IPR011011 Zinc finger, FYVE/PHD-type

IPR017455 Zinc finger, FYVE-related

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 26

cDNA 21

Primer pair 5

Antibodies 2

Microarray probesets 10

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MGD-MRK-37142, MGI:108105, MGI:2143680

Summaries

All 56

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rufy2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93740	Chr10:62816012-62816040 (+)	24 bp
Tssr93741	Chr10:62816059-62816070 (+)	63 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24