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Polr3b Gene Detail
Summary
  • Symbol
    Polr3b
  • Name
    polymerase (RNA) III (DNA directed) polypeptide B
  • Synonyms
    2700078H01Rik, A330032P03Rik, RPC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917678
    NCBI Gene: 70428
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:84458156-84563042 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 41.58 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    923 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917678
protein coding gene Chr10:84458156-84563042 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017593
protein coding gene Chr10:85495674-85607967 (+)
A/J MGP_AJ_G0017573
protein coding gene Chr10:82596843-82702359 (+)
AKR/J MGP_AKRJ_G0017532
protein coding gene Chr10:84891938-85005026 (+)
BALB/cJ MGP_BALBcJ_G0017536
protein coding gene Chr10:82845959-82949711 (+)
C3H/HeJ MGP_C3HHeJ_G0017358
protein coding gene Chr10:84976428-85091442 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017993
protein coding gene Chr10:88394973-88514114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015677
protein coding gene Chr10:78419453-78522267 (+)
CAST/EiJ MGP_CASTEiJ_G0016925
protein coding gene Chr10:84831437-84938304 (+)
CBA/J MGP_CBAJ_G0017328
protein coding gene Chr10:92105351-92225469 (+)
DBA/2J MGP_DBA2J_G0017434
protein coding gene Chr10:81739386-81843874 (+)
FVB/NJ MGP_FVBNJ_G0017428
protein coding gene Chr10:80974270-81080867 (+)
LP/J MGP_LPJ_G0017506
protein coding gene Chr10:86136331-86242121 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017456
protein coding gene Chr10:93701563-93810009 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018030
protein coding gene Chr10:84817893-84924450 (+)
PWK/PhJ MGP_PWKPhJ_G0016706
protein coding gene Chr10:81599900-81707254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016495
protein coding gene Chr10:83440299-83550860 (+)
WSB/EiJ MGP_WSBEiJ_G0016984
protein coding gene Chr10:84803817-84913415 (+)



Homology
more
  • Human Ortholog
    POLR3B, RNA polymerase III subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR3B, RNA polymerase III subunit B
  • Synonyms
    C128, CMT1I, HLD8, INMAP, RPC2
  • Links
    NCBI Gene ID: 55703
    neXtProt AC: NX_Q9NW08
    UniProt: Q9NW08

  • Chr Location
    12q23.3; chr12:106357748-106510198 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human POLR3B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70428 NCBI Gene Model | MGI Sequence Detail 104887 C57BL/6J ±  kb
transcript NM_027423 RefSeq | MGI Sequence Detail 4997 Not Specified  
polypeptide P59470 UniProt | EBI | MGI Sequence Detail 1133 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013001 DNA-directed RNA polymerase III subunit RPC2
  • EC
  • InterPro Domains
    IPR015712 DNA-directed RNA polymerase, subunit 2
    IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
    IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
    IPR007121 RNA polymerase, beta subunit, conserved site
    IPR007644 RNA polymerase, beta subunit, protrusion
    IPR007642 RNA polymerase Rpb2, domain 2
    IPR037034 RNA polymerase Rpb2, domain 2 superfamily
    IPR007645 RNA polymerase Rpb2, domain 3
    IPR007646 RNA polymerase Rpb2, domain 4
    IPR007647 RNA polymerase Rpb2, domain 5
    IPR007641 RNA polymerase Rpb2, domain 7
    IPR014724 RNA polymerase Rpb2, OB-fold
Molecular
Reagents
less
  • All nucleic 75
    cDNA 75

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143941, MGI:2443266
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:278810 Choquet K, et al., The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis. Mol Brain. 2019 Jun 20;12(1):59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory