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Dnah17 Gene Detail
Summary
  • Symbol
    Dnah17
  • Name
    dynein, axonemal, heavy chain 17
  • Synonyms
    2810003K23Rik, Dnahc17, Dnahcl1, LOC382552
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917176
    NCBI Gene: 69926
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117912549-118021460 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917176
 protein coding gene Chr11:117912549-118021684 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019461
 protein coding gene Chr11:122328075-122441239 (-)
A/J MGP_AJ_G0019429
 protein coding gene Chr11:116899699-117010680 (-)
AKR/J MGP_AKRJ_G0019399
 protein coding gene Chr11:120451506-120560851 (-)
BALB/cJ MGP_BALBcJ_G0019404
 protein coding gene Chr11:117266713-117374802 (-)
C3H/HeJ MGP_C3HHeJ_G0019210
 protein coding gene Chr11:120749250-120861715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019853
 protein coding gene Chr11:126066829-126186799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017478
 protein coding gene Chr11:113909987-114021454 (-)
CAST/EiJ MGP_CASTEiJ_G0018764
 protein coding gene Chr11:122166576-122286539 (-)
CBA/J MGP_CBAJ_G0019181
 protein coding gene Chr11:131004966-131125981 (-)
DBA/2J MGP_DBA2J_G0019293
 protein coding gene Chr11:116292235-116401124 (-)
FVB/NJ MGP_FVBNJ_G0019285
 protein coding gene Chr11:115923191-116038553 (-)
LP/J MGP_LPJ_G0019363
 protein coding gene Chr11:122645868-122760545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019318
 protein coding gene Chr11:129971111-130085944 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019892
 protein coding gene Chr11:121106655-121220563 (-)
PWK/PhJ MGP_PWKPhJ_G0018530
 protein coding gene Chr11:117657970-117769404 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018322
 protein coding gene Chr11:120834923-120943518 (-)
WSB/EiJ MGP_WSBEiJ_G0018816
 protein coding gene Chr11:121072283-121184277 (-)



Homology
more
  • Human Ortholog
    DNAH17, dynein axonemal heavy chain 17
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH17, dynein axonemal heavy chain 17
  • Synonyms
    DNAHL1, DNEL2, SPGF39
  • Links
    NCBI Gene ID: 8632
    neXtProt AC: NX_Q9UFH2
    UniProt: Q9UFH2

  • Chr Location
    17q25.3; chr17:78423697-78577396 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnah17 mouse models; 1 with human DNAH17 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit oligozoospermia, globozoospermia, and asthenozoospermia associated with abnormal sperm axoneme morphology. Mice homozygolus for a point mutation allele exhibit reduced fertility and abnormal sperm axoneme morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033987 Ensembl Gene Model | MGI Sequence Detail 108912 C57BL/6J ±  kb
    transcript ENSMUST00000132685 Ensembl | MGI Sequence Detail 13612 Not Applicable  
    polypeptide ENSMUSP00000120542 Ensembl | MGI Sequence Detail 4459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000006561 dynein axonemal heavy chain 17
      (term hierarchy)
    • InterPro Domains
      IPR026983 Dynein heavy chain
      IPR041589 Dynein heavy chain 3, AAA+ lid domain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR013602 Dynein heavy chain, linker
      IPR042228 Dynein heavy chain, linker, subdomain 3
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR013594 Dynein heavy chain, tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2686024
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:43700 Neesen J, et al., Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Gene. 1997 Oct 24;200(1-2):193-202
    • Latest
      J:334131 Zhang B, et al., Novel loss-of-function variants in DNAH17 cause multiple morphological abnormalities of the sperm flagella in humans and mice. Clin Genet. 2021 Jan;99(1):176-186
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory