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2010003K11Rik Gene Detail
Summary
  • Symbol
    2010003K11Rik
  • Name
    RIKEN cDNA 2010003K11 gene
  • Synonyms
    Faci
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917111
    NCBI Gene: 69861
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4546816-4548611 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.07 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917111
 protein coding gene Chr19:4546816-4548611 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024665
 protein coding gene Chr19:1374012-1375805 (-)
A/J MGP_AJ_G0024631
 protein coding gene Chr19:1304628-1306421 (-)
AKR/J MGP_AKRJ_G0024604
 protein coding gene Chr19:1344711-1346504 (-)
BALB/cJ MGP_BALBcJ_G0024631
 protein coding gene Chr19:1301171-1302964 (-)
C3H/HeJ MGP_C3HHeJ_G0024399
 protein coding gene Chr19:1347299-1349092 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025079
 protein coding gene Chr19:1423413-1425206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022508
 protein coding gene Chr19:1245254-1247046 (-)
CAST/EiJ MGP_CASTEiJ_G0023871
 protein coding gene Chr19:1352406-1354201 (-)
CBA/J MGP_CBAJ_G0024370
 protein coding gene Chr19:1499396-1501188 (-)
DBA/2J MGP_DBA2J_G0024498
 protein coding gene Chr19:1267622-1269414 (-)
FVB/NJ MGP_FVBNJ_G0024465
 protein coding gene Chr19:1291384-1293177 (-)
LP/J MGP_LPJ_G0024584
 protein coding gene Chr19:1385948-1387741 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024495
 protein coding gene Chr19:1411263-1413056 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025126
 protein coding gene Chr19:1347079-1348872 (-)
PWK/PhJ MGP_PWKPhJ_G0023617
 protein coding gene Chr19:1323338-1325133 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023422
 protein coding gene Chr19:1333583-1335380 (-)
WSB/EiJ MGP_WSBEiJ_G0023933
 protein coding gene Chr19:1336078-1337871 (-)



Homology
more
  • Human Ortholog
    C11orf86, chromosome 11 open reading frame 86
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C11orf86, chromosome 11 open reading frame 86
  • Synonyms
    FACI
  • Links
    NCBI Gene ID: 254439
    neXtProt AC: NX_A6NJI1
    UniProt: A6NJI1

  • Chr Location
    11q13.2; chr11:66975277-66977009 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased intestinal triglyceride absorption and increased susceptibility to high-fat diet-induced obesity, hepatic steatosis, hyperlipidemia, and insulin resistance.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69861 NCBI Gene Model | MGI Sequence Detail 1796 C57BL/6J ±  kb
    transcript NM_027237 RefSeq | MGI Sequence Detail 1167 C57BL/6  
    polypeptide Q8VC23 UniProt | EBI | MGI Sequence Detail 124 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 2
    References
    more
    • Summaries
      All 19
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326325 Cheng Y, et al., FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity. Cell Mol Gastroenterol Hepatol. 2022 Jan 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory