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Pold4 Gene Detail
Summary
  • Symbol
    Pold4
  • Name
    polymerase (DNA-directed), delta 4
  • Synonyms
    2410012M21Rik, DNA polymerase delta smallest subunit p12, p12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916995
    NCBI Gene: 69745
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4281953-4283688 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916995
protein coding gene Chr19:4281947-4283688 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024658
protein coding gene Chr19:1076208-1077940 (+)
A/J MGP_AJ_G0024624
protein coding gene Chr19:1034420-1036138 (+)
AKR/J MGP_AKRJ_G0024597
protein coding gene Chr19:1062595-1064321 (+)
BALB/cJ MGP_BALBcJ_G0024624
protein coding gene Chr19:1024972-1026702 (+)
C3H/HeJ MGP_C3HHeJ_G0024392
protein coding gene Chr19:1059413-1061143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025072
protein coding gene Chr19:1113034-1114766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022501
protein coding gene Chr19:977889-979596 (+)
CAST/EiJ MGP_CASTEiJ_G0023864
protein coding gene Chr19:1073283-1075027 (+)
CBA/J MGP_CBAJ_G0024363
protein coding gene Chr19:1176875-1178599 (+)
DBA/2J MGP_DBA2J_G0024491
protein coding gene Chr19:994931-996655 (+)
FVB/NJ MGP_FVBNJ_G0024458
protein coding gene Chr19:1004155-1006729 (+)
LP/J MGP_LPJ_G0024577
protein coding gene Chr19:1069389-1071205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024488
protein coding gene Chr19:1118195-1119921 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025119
protein coding gene Chr19:1060213-1061945 (+)
PWK/PhJ MGP_PWKPhJ_G0023610
protein coding gene Chr19:1048371-1050091 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023415
protein coding gene Chr19:1045048-1047614 (+)
WSB/EiJ MGP_WSBEiJ_G0023926
protein coding gene Chr19:1050462-1052188 (+)



Homology
more
  • Human Ortholog
    POLD4, DNA polymerase delta 4, accessory subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLD4, DNA polymerase delta 4, accessory subunit
  • Synonyms
    p12, POLDS
  • Links
    NCBI Gene ID: 57804
    neXtProt AC: NX_Q9HCU8
    UniProt: Q9HCU8

  • Chr Location
    11q13.2; chr11:67350765-67356972 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased lifespan and decreased incidence of liver tumors. Another null allele shows decreased leukocyte numbers and decreased circulating glucose and calcium levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024854 Ensembl Gene Model | MGI Sequence Detail 1736 C57BL/6J ±  kb
    transcript ENSMUST00000025773 Ensembl | MGI Sequence Detail 913 Not Applicable  
    polypeptide ENSMUSP00000025773 Ensembl | MGI Sequence Detail 107 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147559, MGI:2147697
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:331883 Gu X, et al., Pold4 is dispensable for mouse development, DNA replication and DNA repair. Gene. 2023 Jan 30;851:147029

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory