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Lrr1 Gene Detail
Summary
  • Symbol
    Lrr1
  • Name
    leucine rich repeat protein 1
  • Synonyms
    2410005L11Rik, LRR-1, Ppil5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916956
    NCBI Gene: 69706
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69215588-69225783 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 28.73 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916956
 protein coding gene Chr12:69215588-69225786 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019786
 protein coding gene Chr12:68830962-68841428 (+)
A/J MGP_AJ_G0019744
 protein coding gene Chr12:66276579-66290559 (+)
AKR/J MGP_AKRJ_G0019720
 protein coding gene Chr12:68264781-68275427 (+)
BALB/cJ MGP_BALBcJ_G0019724
 protein coding gene Chr12:66741947-66752146 (+)
C3H/HeJ MGP_C3HHeJ_G0019530
 protein coding gene Chr12:68730693-68740859 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020176
 protein coding gene Chr12:71024209-71034162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017796
 protein coding gene Chr12:63825567-63835468 (+)
CAST/EiJ MGP_CASTEiJ_G0019081
 protein coding gene Chr12:63476598-63488037 (+)
CBA/J MGP_CBAJ_G0019499
 protein coding gene Chr12:73650982-73661315 (+)
DBA/2J MGP_DBA2J_G0019615
 protein coding gene Chr12:66196602-66206734 (+)
FVB/NJ MGP_FVBNJ_G0019603
 protein coding gene Chr12:65089312-65100559 (+)
LP/J MGP_LPJ_G0019687
 protein coding gene Chr12:68789875-68801234 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019641
 protein coding gene Chr12:77001320-77013134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020211
 protein coding gene Chr12:67730172-67740290 (+)
PWK/PhJ MGP_PWKPhJ_G0018847
 protein coding gene Chr12:60458095-60464622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018642
 protein coding gene Chr12:62125970-62136262 (+)
WSB/EiJ MGP_WSBEiJ_G0019132
 protein coding gene Chr12:68348870-68359677 (+)



Homology
more
  • Human Ortholog
    LRR1, leucine rich repeat protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRR1, leucine rich repeat protein 1
  • Synonyms
    4-1BBLRR, LRR-1, PPIL5
  • Links
    NCBI Gene ID: 122769
    neXtProt AC: NX_Q96L50
    UniProt: Q96L50

  • Chr Location
    14q21.3; chr14:49598761-49614672 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034883 Ensembl Gene Model | MGI Sequence Detail 10196 C57BL/6J ±  kb
transcript ENSMUST00000110621 Ensembl | MGI Sequence Detail 1500 Not Applicable  
polypeptide ENSMUSP00000106251 Ensembl | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144954
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory