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Pex5l Gene Detail
Summary
  • Symbol
    Pex5l
  • Name
    peroxisomal biogenesis factor 5-like
  • Synonyms
    1700016J08Rik, Pex2, PXR2, TRIP8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916672
    NCBI Gene: 58869
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:33003557-33197396 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 15.94 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5529 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916672
 protein coding gene Chr3:33002075-33197470 (-)
129S1/SvImJ ENSMUSG00200023926
 protein coding gene Chr3:29737556-29931026 (-)
A/J ENSMUSG00195021110
 protein coding gene Chr3:29729464-29923913 (-)
AKR/J ENSMUSG00220008400
 protein coding gene Chr3:29764218-29957874 (-)
BALB/cJ ENSMUSG00180031450
 protein coding gene Chr3:29854304-30047982 (-)
C3H/HeJ ENSMUSG00175027616
 protein coding gene Chr3:29722259-29916689 (-)
C57BL/6NJ ENSMUSG00215011508
 protein coding gene Chr3:30128358-30322047 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024924
 protein coding gene Chr3:27935017-28134990 (-)
CAST/EiJ ENSTCUG00005024042
 protein coding gene Chr3:29618803-29815872 (-)
CBA/J ENSMUSG00210033262
 protein coding gene Chr3:29808206-30002626 (-)
DBA/2J ENSMUSG00185008704
 protein coding gene Chr3:30059022-30252672 (-)
FVB/NJ ENSMUSG00205007551
 protein coding gene Chr3:29244817-29438291 (-)
JF1/MsJ ENSUMUG00000003226
 protein coding gene Chr3:29490490-29687214 (-)
LP/J ENSMUSG00230023032
 protein coding gene Chr3:31984023-32177469 (-)
NOD/ShiLtJ ENSMUSG00190028124
 protein coding gene Chr3:30055160-30248831 (-)
NZO/HlLtJ ENSMUSG00225006548
 protein coding gene Chr3:34602026-34795463 (-)
PWK/PhJ ENSLUMG00010034684
 protein coding gene Chr3:29532388-29727809 (-)
SPRET/EiJ ENSMSPG00010024087
 protein coding gene Chr3:29903785-30115166 (-)
WSB/EiJ ENSIUOG00005035227
 protein coding gene Chr3:30052716-30246206 (-)



Homology
more
  • Human Ortholog
    PEX5L, peroxisomal biogenesis factor 5 like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX5L, peroxisomal biogenesis factor 5 like
  • Synonyms
    PEX5R, PEX5RP, PXR2, PXR2B, TRIP8b
  • Links
    NCBI Gene ID: 51555
    UniProt: Q8IYB4

  • Chr Location
    3q26.33; chr3:179794958-180037053 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation lacking isoform b exhibit reduced hyperpolarization-activated current in CA1 pyramidal neuron, impaired motor learning, impaired nest-building, decreased startle reflex, and decreased depression-related behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027674 Ensembl Gene Model | MGI Sequence Detail 193840 C57BL/6J ±  kb
transcript ENSMUST00000193681 Ensembl | MGI Sequence Detail 3620 Not Applicable  
polypeptide ENSMUSP00000141454 Ensembl | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
References
more
  • Summaries
    All 53
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory