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Ing2 Gene Detail
Summary
  • Symbol
    Ing2
  • Name
    inhibitor of growth family, member 2
  • Synonyms
    2810011M06Rik, Ing1l, ING2, P33ING2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916510
    NCBI Gene: 69260
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:48120213-48128591 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.87 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916510
 protein coding gene Chr8:48120213-48128627 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033598
 protein coding gene Chr8:46850010-46858383 (-)
A/J MGP_AJ_G0033580
 protein coding gene Chr8:45016824-45025202 (-)
AKR/J MGP_AKRJ_G0033505
 protein coding gene Chr8:46323607-46331985 (-)
BALB/cJ MGP_BALBcJ_G0033577
 protein coding gene Chr8:45197540-45205918 (-)
C3H/HeJ MGP_C3HHeJ_G0033286
 protein coding gene Chr8:46891676-46900054 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034093
 protein coding gene Chr8:48607341-48615719 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031042
 protein coding gene Chr8:41247245-41255621 (-)
CAST/EiJ MGP_CASTEiJ_G0032612
 protein coding gene Chr8:46338828-46348252 (-)
CBA/J MGP_CBAJ_G0033265
 protein coding gene Chr8:50544448-50552825 (-)
DBA/2J MGP_DBA2J_G0033418
 protein coding gene Chr8:44819289-44827667 (-)
FVB/NJ MGP_FVBNJ_G0033359
 protein coding gene Chr8:44293343-44301718 (-)
LP/J MGP_LPJ_G0033506
 protein coding gene Chr8:46843967-46852344 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033404
 protein coding gene Chr8:50582489-50590867 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034111
 protein coding gene Chr8:46509820-46518871 (-)
PWK/PhJ MGP_PWKPhJ_G0032320
 protein coding gene Chr8:44341163-44349567 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032156
 protein coding gene Chr8:45674420-45683044 (-)
WSB/EiJ MGP_WSBEiJ_G0032728
 protein coding gene Chr8:46768836-46777212 (-)



Homology
more
  • Human Ortholog
    ING2, inhibitor of growth family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ING2, inhibitor of growth family member 2
  • Synonyms
    ING1L, p33ING2
  • Links
    NCBI Gene ID: 3622
    neXtProt AC: NX_Q9H160
    UniProt: Q9H160

  • Chr Location
    4q35.1; chr4:183505058-183512429 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes impaired spermatogenesis and male infertility associated with teratozoospermia, seminiferous tubule degeneration, germ cell depletion, arrest of male meiosis and enhanced testicular apoptosis, and leads to an increased incidence of soft tissue sarcomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    204
  • cDNA Data
    23
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063049 Ensembl Gene Model | MGI Sequence Detail 8379 C57BL/6J ±  kb
    transcript ENSMUST00000080353 Ensembl | MGI Sequence Detail 2812 Not Applicable  
    polypeptide ENSMUSP00000079226 Ensembl | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:320044 Zhang Y, et al., SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998 Jun;1(7):1021-31
    • Latest
      J:243422 Streubel G, et al., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017 Aug 01;36(15):2216-2232
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory