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Polr2d Gene Detail
Summary
  • Symbol
    Polr2d
  • Name
    polymerase (RNA) II (DNA directed) polypeptide D
  • Synonyms
    2310002G05Rik, 2610028L19Rik, HSRBP4, RBP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916491
    NCBI Gene: 69241
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:31922212-31929754 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 17.85 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916491
 protein coding gene Chr18:31922178-31929762 (+)
129S1/SvImJ ENSMUSG00200016108
 protein coding gene Chr18:28919515-28927068 (+)
A/J ENSMUSG00195002411
 protein coding gene Chr18:29111260-29118815 (+)
AKR/J ENSMUSG00220011160
 protein coding gene Chr18:29068819-29076373 (+)
BALB/cJ ENSMUSG00180003434
 protein coding gene Chr18:29575894-29583436 (+)
C3H/HeJ ENSMUSG00175023216
 protein coding gene Chr18:29091201-29098743 (+)
C57BL/6NJ ENSMUSG00215017093
 protein coding gene Chr18:28792051-28799593 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022066
 protein coding gene Chr18:29134318-29143203 (+)
CAST/EiJ ENSTCUG00005016114
 protein coding gene Chr18:28717852-28725375 (+)
CBA/J ENSMUSG00210016073
 protein coding gene Chr18:29110191-29117746 (+)
DBA/2J ENSMUSG00185022259
 protein coding gene Chr18:29044566-29052121 (+)
FVB/NJ ENSMUSG00205020324
 protein coding gene Chr18:28778333-28785887 (+)
JF1/MsJ ENSUMUG00000014922
 protein coding gene Chr18:29168566-29176142 (+)
LP/J ENSMUSG00230043333
 protein coding gene Chr18:31117143-31124696 (+)
NOD/ShiLtJ ENSMUSG00190006481
 protein coding gene Chr18:28838790-28846345 (+)
NZO/HlLtJ ENSMUSG00225046279
 protein coding gene Chr18:31042332-31049887 (+)
PWK/PhJ ENSLUMG00010003091
 protein coding gene Chr18:29315839-29323411 (+)
SPRET/EiJ ENSMSPG00010021213
 protein coding gene Chr18:29338004-29345532 (+)
WSB/EiJ ENSIUOG00005002667
 protein coding gene Chr18:28849621-28857174 (+)



Homology
more
  • Human Ortholog
    POLR2D, RNA polymerase II subunit D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2D, RNA polymerase II subunit D
  • Synonyms
    HSRBP4, HSRPB4, RBP4, RPB16, RPB4
  • Links
    NCBI Gene ID: 5433
    UniProt: O15514

  • Chr Location
    2q14.3; chr2:127843553-127858155 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    83
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024258 Ensembl Gene Model | MGI Sequence Detail 7543 C57BL/6J ±  kb
transcript ENSMUST00000025106 Ensembl | MGI Sequence Detail 1015 Not Applicable  
polypeptide ENSMUSP00000025106 Ensembl | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 83
    cDNA 83

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916771
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:62678 Phillips RL, et al., The genetic program of hematopoietic stem cells. Science. 2000 Jun 2;288(5471):1635-40
  • Latest
    J:341543 Meng TG, et al., NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. Adv Sci (Weinh). 2023 Sep;10(27):e2301940
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory