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Nexn Gene Detail
Summary
  • Symbol
    Nexn
  • Name
    nexilin
  • Synonyms
    1110046H09Rik, nF actin binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916060
    NCBI Gene: 68810
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:151942619-151971987 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 77.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916060
 protein coding gene Chr3:151942619-151972000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027989
 protein coding gene Chr3:156089387-156121920 (-)
A/J MGP_AJ_G0027948
 protein coding gene Chr3:150430669-150460452 (-)
AKR/J MGP_AKRJ_G0027914
 protein coding gene Chr3:154388658-154419704 (-)
BALB/cJ MGP_BALBcJ_G0027960
 protein coding gene Chr3:150267318-150297353 (-)
C3H/HeJ MGP_C3HHeJ_G0027690
 protein coding gene Chr3:154833137-154865115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028403
 protein coding gene Chr3:161236075-161266228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025741
 protein coding gene Chr3:145266717-145296247 (-)
CAST/EiJ MGP_CASTEiJ_G0027143
 protein coding gene Chr3:154908575-154938677 (-)
CBA/J MGP_CBAJ_G0027665
 protein coding gene Chr3:167018837-167050933 (-)
DBA/2J MGP_DBA2J_G0027805
 protein coding gene Chr3:149536391-149567145 (-)
FVB/NJ MGP_FVBNJ_G0027772
 protein coding gene Chr3:146913285-146942578 (-)
LP/J MGP_LPJ_G0027916
 protein coding gene Chr3:157465243-157494815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027805
 protein coding gene Chr3:175551337-175582436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028462
 protein coding gene Chr3:154083445-154114919 (-)
PWK/PhJ MGP_PWKPhJ_G0026866
 protein coding gene Chr3:149422274-149452167 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026694
 protein coding gene Chr3:152242792-152272595 (-)
WSB/EiJ MGP_WSBEiJ_G0027223
 protein coding gene Chr3:155092562-155122320 (-)



Homology
more
  • Human Ortholog
    NEXN, nexilin F-actin binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEXN, nexilin F-actin binding protein
  • Synonyms
    CMH20, NELIN
  • Links
    NCBI Gene ID: 91624
    neXtProt AC: NX_Q0ZGT2
    UniProt: Q0ZGT2

  • Chr Location
    1p31.1; chr1:77888513-77943895 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Nexn mouse models; 2 with human NEXN associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality with endomyocardial fibroelastosis, cardiac hypertrophy and dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    10
  • cDNA Data
    58
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039103 Ensembl Gene Model | MGI Sequence Detail 29369 C57BL/6J ±  kb
    transcript ENSMUST00000199423 Ensembl | MGI Sequence Detail 2016 Not Applicable  
    polypeptide ENSMUSP00000142936 Ensembl | MGI Sequence Detail 671 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 58
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139594
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333882 Ehrman JM, et al., Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants. J Neurosci. 2022 Apr 20;42(16):3344-3364
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory