About   Help   FAQ
Arel1 Gene Detail
Summary
  • Symbol
    Arel1
  • Name
    apoptosis resistant E3 ubiquitin protein ligase 1
  • Synonyms
    1110018G07Rik, mKIAA0317
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915747
    NCBI Gene: 68497
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84964922-85017674 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915747
 protein coding gene Chr12:84964914-85017674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019948
 protein coding gene Chr12:85666418-85721524 (-)
A/J MGP_AJ_G0019905
 protein coding gene Chr12:82417809-82470723 (-)
AKR/J MGP_AKRJ_G0019881
 protein coding gene Chr12:84644093-84696107 (-)
BALB/cJ MGP_BALBcJ_G0019885
 protein coding gene Chr12:82747203-82799598 (-)
C3H/HeJ MGP_C3HHeJ_G0019691
 protein coding gene Chr12:85122241-85176275 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020336
 protein coding gene Chr12:88127755-88187435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017954
 protein coding gene Chr12:79304365-79356877 (-)
CAST/EiJ MGP_CASTEiJ_G0019240
 protein coding gene Chr12:80087153-80141267 (-)
CBA/J MGP_CBAJ_G0019662
 protein coding gene Chr12:91521790-91585819 (-)
DBA/2J MGP_DBA2J_G0019777
 protein coding gene Chr12:81937677-81989852 (-)
FVB/NJ MGP_FVBNJ_G0019763
 protein coding gene Chr12:80897420-80950098 (-)
LP/J MGP_LPJ_G0019849
 protein coding gene Chr12:85539281-85594107 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019802
 protein coding gene Chr12:94406098-94460729 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020370
 protein coding gene Chr12:84250175-84303809 (-)
PWK/PhJ MGP_PWKPhJ_G0019004
 protein coding gene Chr12:76425894-76479704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018799
 protein coding gene Chr12:78724571-78780749 (-)
WSB/EiJ MGP_WSBEiJ_G0019292
 protein coding gene Chr12:84970835-85025147 (-)



Homology
more
  • Human Ortholog
    AREL1, apoptosis resistant E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AREL1, apoptosis resistant E3 ubiquitin protein ligase 1
  • Synonyms
    FIEL1, KIAA0317
  • Links
    NCBI Gene ID: 9870
    neXtProt AC: NX_O15033
    UniProt: O15033

  • Chr Location
    14q24.3; chr14:74653437-74713117 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042350 Ensembl Gene Model | MGI Sequence Detail 52753 C57BL/6J ±  kb
transcript ENSMUST00000043169 Ensembl | MGI Sequence Detail 5446 Not Applicable  
polypeptide ENSMUSP00000048780 Ensembl | MGI Sequence Detail 823 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144874, MGI:2145051
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:280563 Lear TB, et al., KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. JCI Insight. 2019 Oct 3;4(19)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory