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Mob1b Gene Detail
Summary
  • Symbol
    Mob1b
  • Name
    MOB kinase activator 1B
  • Synonyms
    1110003E08Rik, Mobkl1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915723
    NCBI Gene: 68473
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:88868730-88906314 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.92 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915723
 protein coding gene Chr5:88868714-88912079 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029712
 protein coding gene Chr5:89727691-89774174 (+)
A/J MGP_AJ_G0029678
 protein coding gene Chr5:86190726-86235063 (+)
AKR/J MGP_AKRJ_G0029624
 protein coding gene Chr5:89022216-89068717 (+)
BALB/cJ MGP_BALBcJ_G0029688
 protein coding gene Chr5:87094189-87140139 (+)
C3H/HeJ MGP_C3HHeJ_G0029411
 protein coding gene Chr5:89369286-89420948 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030142
 protein coding gene Chr5:93369553-93421122 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027378
 protein coding gene Chr5:81993929-82038997 (+)
CAST/EiJ MGP_CASTEiJ_G0028821
 protein coding gene Chr5:88793143-88841592 (+)
CBA/J MGP_CBAJ_G0029380
 protein coding gene Chr5:96494494-96542810 (+)
DBA/2J MGP_DBA2J_G0029525
 protein coding gene Chr5:86252057-86296542 (+)
FVB/NJ MGP_FVBNJ_G0029484
 protein coding gene Chr5:85171212-85213952 (+)
LP/J MGP_LPJ_G0029613
 protein coding gene Chr5:90128295-90175185 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029513
 protein coding gene Chr5:101512335-101559601 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030176
 protein coding gene Chr5:88542883-88584702 (+)
PWK/PhJ MGP_PWKPhJ_G0028540
 protein coding gene Chr5:85336194-85381451 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028375
 protein coding gene Chr5:87975556-88022063 (+)
WSB/EiJ MGP_WSBEiJ_G0028900
 protein coding gene Chr5:88928663-88975015 (+)



Homology
more
  • Human Ortholog
    MOB1B, MOB kinase activator 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOB1B, MOB kinase activator 1B
  • Synonyms
    MATS2, MOB4A, MOBKL1A
  • Links
    NCBI Gene ID: 92597
    neXtProt AC: NX_Q7L9L4
    UniProt: Q7L9L4

  • Chr Location
    4q13.3; chr4:70901851-71022449 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    51 phenotypes from multigenic genotypes
    6 images
    22 phenotype references
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    9
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Mob1b
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    21 strains or lines available
Mice homozygous for a gene trap allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    19
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68473 NCBI Gene Model | MGI Sequence Detail 37585 C57BL/6J ±  kb
transcript NM_026735 RefSeq | MGI Sequence Detail 3171 C57BL/6  
polypeptide Q8BPB0 UniProt | EBI | MGI Sequence Detail 216 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141027
References
more
  • Summaries
    All 53
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 22
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:332523 Soyama H, et al., Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2123134119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory