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Sirt5 Gene Detail
Summary
  • Symbol
    Sirt5
  • Name
    sirtuin 5
  • Synonyms
    0610012J09Rik, 1500032M05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915596
    NCBI Gene: 68346
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:43518972-43548679 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 21.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915596
 protein coding gene Chr13:43518849-43549073 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020498
 protein coding gene Chr13:41962948-41989852 (+)
A/J MGP_AJ_G0020452
 protein coding gene Chr13:40541743-40560034 (+)
AKR/J MGP_AKRJ_G0020430
 protein coding gene Chr13:41652218-41675334 (+)
BALB/cJ MGP_BALBcJ_G0020448
 protein coding gene Chr13:40745912-40768724 (+)
C3H/HeJ MGP_C3HHeJ_G0020247
 protein coding gene Chr13:41524640-41542161 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020881
 protein coding gene Chr13:43253567-43276820 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018468
 protein coding gene Chr13:38636129-38660514 (+)
CAST/EiJ MGP_CASTEiJ_G0019762
 protein coding gene Chr13:41357491-41379576 (+)
CBA/J MGP_CBAJ_G0020208
 protein coding gene Chr13:45094906-45117517 (+)
DBA/2J MGP_DBA2J_G0020330
 protein coding gene Chr13:40098083-40120435 (+)
FVB/NJ MGP_FVBNJ_G0020309
 protein coding gene Chr13:39622272-39647116 (+)
LP/J MGP_LPJ_G0020405
 protein coding gene Chr13:42205070-42224120 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020338
 protein coding gene Chr13:44991936-45027701 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020924
 protein coding gene Chr13:41319586-41343654 (+)
PWK/PhJ MGP_PWKPhJ_G0019517
 protein coding gene Chr13:40211889-40234733 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019347
 protein coding gene Chr13:39946015-39969077 (+)
WSB/EiJ MGP_WSBEiJ_G0019824
 protein coding gene Chr13:41629193-41654118 (+)



Homology
more
  • Human Ortholog
    SIRT5, sirtuin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIRT5, sirtuin 5
  • Synonyms
    SIR2L5
  • Links
    NCBI Gene ID: 23408
    neXtProt AC: NX_Q9NXA8
    UniProt: Q9NXA8

  • Chr Location
    6p23; chr6:13574227-13615158 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and grossly healthy and do not exhibit globally increased mitochondrial protein acetylation levels relative to wild-type controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    13
  • cDNA Data
    20
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054021 Ensembl Gene Model | MGI Sequence Detail 29708 C57BL/6J ±  kb
    transcript ENSMUST00000221515 Ensembl | MGI Sequence Detail 1793 Not Applicable  
    polypeptide ENSMUSP00000152526 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917010, MGI:2145383
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 4
      Gene Ontology 18
      Phenotypes 49
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:340143 Mao J, et al., SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis. Exp Mol Med. 2023 Jan;55(1):253-268
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory