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Crip2 Gene Detail
Summary
  • Symbol
    Crip2
  • Name
    cysteine rich protein 2
  • Synonyms
    0610010I23Rik, Crp, CRP4, ESP1, Hlp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915587
    NCBI Gene: 68337
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113103856-113109126 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.57 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915587
 protein coding gene Chr12:113103856-113109126 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020172
 protein coding gene Chr12:115636623-115641557 (+)
A/J MGP_AJ_G0020128
 protein coding gene Chr12:111158458-111163713 (+)
AKR/J MGP_AKRJ_G0020103
 protein coding gene Chr12:114389986-114394920 (+)
BALB/cJ MGP_BALBcJ_G0020113
 protein coding gene Chr12:111624279-111629213 (+)
C3H/HeJ MGP_C3HHeJ_G0019915
 protein coding gene Chr12:114911615-114916870 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020558
 protein coding gene Chr12:119182003-119186937 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018172
 protein coding gene Chr12:107592280-107597630 (+)
CAST/EiJ MGP_CASTEiJ_G0019455
 protein coding gene Chr12:109755977-109762078 (+)
CBA/J MGP_CBAJ_G0019882
 protein coding gene Chr12:123749679-123754934 (+)
DBA/2J MGP_DBA2J_G0019999
 protein coding gene Chr12:110659893-110664827 (+)
FVB/NJ MGP_FVBNJ_G0019984
 protein coding gene Chr12:109503213-109508468 (+)
LP/J MGP_LPJ_G0020073
 protein coding gene Chr12:115456957-115461891 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020022
 protein coding gene Chr12:126836568-126841502 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020587
 protein coding gene Chr12:113906374-113911629 (+)
PWK/PhJ MGP_PWKPhJ_G0019217
 protein coding gene Chr12:105321277-105326759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019021
 protein coding gene Chr12:108086383-108091642 (+)
WSB/EiJ MGP_WSBEiJ_G0019515
 protein coding gene Chr12:114820616-114825871 (+)



Homology
more
  • Human Ortholog
    CRIP2, cysteine rich protein 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRIP2, cysteine rich protein 2
  • Synonyms
    CRIP, CRP2, ESP1
  • Links
    NCBI Gene ID: 1397
    neXtProt AC: NX_P52943
    UniProt: P52943

  • Chr Location
    14q32.33; chr14:105472945-105480170 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display abnormal inflammatory pain responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    148
  • cDNA Data
    10
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68337 NCBI Gene Model | MGI Sequence Detail 5271 C57BL/6J ±  kb
transcript NM_024223 RefSeq | MGI Sequence Detail 1454 ZRU/MplStud  
polypeptide Q9DCT8 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 10
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145057, MGI:2145082
References
more
  • Summaries
    All 50
    Developmental Gene Expression 12
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:31705 Karim MA, et al., Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Genomics. 1996 Jan 15;31(2):167-76
  • Latest
    J:345976 Langst N, et al., Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model. Cells. 2022 Apr 17;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory