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Tsr3 Gene Detail
Summary
  • Symbol
    Tsr3
  • Name
    TSR3 20S rRNA accumulation
  • Synonyms
    0610007P22Rik, 1110014B11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915577
    NCBI Gene: 68327
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25459141-25461773 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915577
 protein coding gene Chr17:25459120-25461773 (+)
129S1/SvImJ ENSMUSG00200052447
 protein coding gene Chr17:20903215-20905828 (+)
A/J ENSMUSG00195054127
 protein coding gene Chr17:21921276-21923897 (+)
AKR/J ENSMUSG00220052968
 protein coding gene Chr17:20967658-20970271 (+)
BALB/cJ ENSMUSG00180044065
 protein coding gene Chr17:21201203-21203816 (+)
C3H/HeJ ENSMUSG00175049205
 protein coding gene Chr17:20959856-20962469 (+)
C57BL/6NJ ENSMUSG00215054176
 protein coding gene Chr17:20967427-20970055 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021228
 protein coding gene Chr17:21073232-21075873 (+)
CAST/EiJ ENSTCUG00005040071
 protein coding gene Chr17:21543132-21545824 (+)
CBA/J ENSMUSG00210046731
 protein coding gene Chr17:20798663-20801276 (+)
DBA/2J ENSMUSG00185037704
 protein coding gene Chr17:23009583-23012204 (+)
FVB/NJ ENSMUSG00205043807
 protein coding gene Chr17:21264241-21266854 (+)
JF1/MsJ ENSUMUG00000045698
 protein coding gene Chr17:22458933-22461561 (+)
LP/J ENSMUSG00230054528
 protein coding gene Chr17:24407827-24410440 (+)
NOD/ShiLtJ ENSMUSG00190032096
 protein coding gene Chr17:20898333-20900954 (+)
NZO/HlLtJ ENSMUSG00225053301
 protein coding gene Chr17:26328698-26331319 (+)
PWK/PhJ ENSLUMG00010053216
 protein coding gene Chr17:20373037-20375665 (+)
SPRET/EiJ ENSMSPG00010036386
 protein coding gene Chr17:21704021-21706655 (+)
WSB/EiJ ENSIUOG00005047968
 protein coding gene Chr17:21646926-21649547 (+)



Homology
more
  • Human Ortholog
    TSR3, TSR3 ribosome maturation factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSR3, TSR3 ribosome maturation factor
  • Synonyms
    C16orf42, HsTsr3
  • Links
    NCBI Gene ID: 115939
    UniProt: Q9UJK0

  • Chr Location
    16p13.3; chr16:1349237-1351878 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, impaired cranial neural crest cell differentiation, and severely underdeveloped facial structures due to regression of ectomesenchymal facial derivatives.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    34
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015126 Ensembl Gene Model | MGI Sequence Detail 2633 C57BL/6J ±  kb
    transcript ENSMUST00000249831 Ensembl | MGI Sequence Detail 1219 Not Applicable  
    polypeptide ENSMUSP00000159936 Ensembl | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000030855 18S rRNA aminocarboxypropyltransferase
      (term hierarchy)
    • EC
      2.5.1.157
    • InterPro Domains
      IPR022968 16S/18S rRNA aminocarboxypropyltransferase Tsr3
      IPR007177 16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal
      IPR007209 RNase L inhibitor RLI-like, possible metal-binding domain
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1926015, MGI:2142654
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:381064 Poverennaya I, et al., Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage. Nat Commun. 2026 Mar 9;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory