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Tox4 Gene Detail
Summary
  • Symbol
    Tox4
  • Name
    TOX high mobility group box family member 4
  • Synonyms
    5730589K01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915389
    NCBI Gene: 268741
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52516603-52532966 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    382 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915389
 protein coding gene Chr14:52516603-52533858 (+)
129S1/SvImJ ENSMUSG00200039751
 protein coding gene Chr14:41312350-41328471 (+)
A/J ENSMUSG00195021579
 protein coding gene Chr14:41541556-41557673 (+)
AKR/J ENSMUSG00220031746
 protein coding gene Chr14:40897463-40913573 (+)
BALB/cJ ENSMUSG00180040091
 protein coding gene Chr14:41170512-41186625 (+)
C3H/HeJ ENSMUSG00175040144
 protein coding gene Chr14:42824685-42840796 (+)
C57BL/6NJ ENSMUSG00215033219
 protein coding gene Chr14:41527234-41544488 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019239
 protein coding gene Chr14:44302180-44319609 (+)
CAST/EiJ ENSTCUG00005048597
 protein coding gene Chr14:43390792-43407167 (+)
CBA/J ENSMUSG00210032823
 protein coding gene Chr14:41524161-41540270 (+)
DBA/2J ENSMUSG00185053194
 protein coding gene Chr14:46442535-46457385 (+)
FVB/NJ ENSMUSG00205040409
 protein coding gene Chr14:40775351-40790208 (+)
JF1/MsJ ENSUMUG00000033748
 protein coding gene Chr14:58351542-58367911 (+)
LP/J ENSMUSG00230052381
 protein coding gene Chr14:58686952-58703063 (+)
NOD/ShiLtJ ENSMUSG00190022298
 protein coding gene Chr14:41209819-41224671 (+)
NZO/HlLtJ ENSMUSG00225050100
 protein coding gene Chr14:48985036-49001145 (+)
PWK/PhJ ENSLUMG00010029657
 protein coding gene Chr14:40737186-40753287 (+)
SPRET/EiJ ENSMSPG00010043655
 protein coding gene Chr14:44435939-44453491 (+)
WSB/EiJ ENSIUOG00005032061
 protein coding gene Chr14:40927957-40942825 (+)



Homology
more
  • Human Ortholog
    TOX4, TOX high mobility group box family member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOX4, TOX high mobility group box family member 4
  • Synonyms
    C14orf92, KIAA0737, LCP1, MIG7
  • Links
    NCBI Gene ID: 9878
    UniProt: O94842

  • Chr Location
    14q11.2; chr14:21476597-21499175 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    106
  • cDNA Data
    20
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268741 NCBI Gene Model | MGI Sequence Detail 16364 C57BL/6J ±  kb
    transcript NM_023434 RefSeq | MGI Sequence Detail 4458 C57BL/6  
    polypeptide Q8BU11 UniProt | EBI | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000031899 TOX high mobility group box family member 4
      (term hierarchy)
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR051365 TOX high mobility group box protein
    • GlyGen
      Q8BU11 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138093
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345645 Huang Y, et al., E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis. Cell Death Dis. 2024 Jan 11;15(1):29
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory