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Pwwp3a Gene Detail
Summary
  • Symbol
    Pwwp3a
  • Name
    PWWP domain containing 3A, DNA repair factor
  • Synonyms
    9430059D04Rik, Mum1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915364
    NCBI Gene: 68114
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80062268-80079737 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915364
 protein coding gene Chr10:80062265-80082415 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017489
 protein coding gene Chr10:80819208-80836677 (+)
A/J MGP_AJ_G0017467
 protein coding gene Chr10:77990669-78008147 (+)
AKR/J MGP_AKRJ_G0017428
 protein coding gene Chr10:80121009-80138476 (+)
BALB/cJ MGP_BALBcJ_G0017429
 protein coding gene Chr10:78221510-78239343 (+)
C3H/HeJ MGP_C3HHeJ_G0017252
 protein coding gene Chr10:80218089-80235558 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017883
 protein coding gene Chr10:83611632-83629096 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015571
 protein coding gene Chr10:74214444-74231272 (+)
CAST/EiJ MGP_CASTEiJ_G0016819
 protein coding gene Chr10:80421281-80438733 (+)
CBA/J MGP_CBAJ_G0017224
 protein coding gene Chr10:86853450-86870901 (+)
DBA/2J MGP_DBA2J_G0017330
 protein coding gene Chr10:77211480-77228949 (+)
FVB/NJ MGP_FVBNJ_G0017324
 protein coding gene Chr10:76395725-76413299 (+)
LP/J MGP_LPJ_G0017401
 protein coding gene Chr10:81296374-81313888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017350
 protein coding gene Chr10:88795495-88813792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017924
 protein coding gene Chr10:80104625-80123586 (+)
PWK/PhJ MGP_PWKPhJ_G0016600
 protein coding gene Chr10:77078276-77095861 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016389
 protein coding gene Chr10:79084329-79104945 (+)
WSB/EiJ MGP_WSBEiJ_G0016879
 protein coding gene Chr10:80142602-80160045 (+)



Homology
more
  • Human Ortholog
    PWWP3A, PWWP domain containing 3A, DNA repair factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PWWP3A, PWWP domain containing 3A, DNA repair factor
  • Synonyms
    EXPAND1, HSPC211, MUM1, MUM-1
  • Links
    NCBI Gene ID: 84939
    neXtProt AC: NX_Q2TAK8
    UniProt: Q2TAK8

  • Chr Location
    19p13.3; chr19:1354711-1378431 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    869
  • Tissues
    24
  • cDNA Data
    119
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020156 Ensembl Gene Model | MGI Sequence Detail 17470 C57BL/6J ±  kb
    transcript ENSMUST00000020365 Ensembl | MGI Sequence Detail 2640 Not Applicable  
    polypeptide ENSMUSP00000020365 Ensembl | MGI Sequence Detail 682 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010775 PWWP domain-containing DNA repair factor 3A
      (term hierarchy)
    • InterPro Domains
      IPR035504 MUM1-like, PWWP domain
      IPR040263 PWWP domain-containing DNA repair factor 3A/3B/4
      IPR048795 PWWP domain-containing DNA repair factor 3A/3B/4, C-terminal
      IPR048765 PWWP domain-containing DNA repair factor 3A/3B/4, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 119

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory