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Tgif2 Gene Detail
Summary
  • Symbol
    Tgif2
  • Name
    TGFB-induced factor homeobox 2
  • Synonyms
    5730599O09Rik, TALE family homeobox
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915299
    NCBI Gene: 228839
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:156681927-156697490 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    22
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915299
 protein coding gene Chr2:156681737-156697490 (+)
129S1/SvImJ ENSMUSG00200015236
 protein coding gene Chr2:153544017-153559548 (+)
A/J ENSMUSG00195018277
 protein coding gene Chr2:153911448-153927011 (+)
AKR/J ENSMUSG00220039203
 protein coding gene Chr17:36030549-36033383 (+)
AKR/J ENSMUSG00220012291
 protein coding gene Chr2:153205786-153221306 (+)
BALB/cJ ENSMUSG00180048619
 protein coding gene Chr2:153366638-153382203 (+)
C3H/HeJ ENSMUSG00175045653
 protein coding gene Chr2:154116948-154132511 (+)
C3H/HeJ ENSMUSG00175035284
 protein coding gene Chr17:36109673-36112482 (+)
C57BL/6NJ ENSMUSG00215024611
 protein coding gene Chr2:153531164-153546729 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024562
 protein coding gene Chr2:148786604-148800440 (+)
CAST/EiJ ENSTCUG00005042842
 protein coding gene Chr2:152503996-152519527 (+)
CBA/J ENSMUSG00210015977
 protein coding gene Chr2:154048083-154063646 (+)
CBA/J ENSMUSG00210038526
 protein coding gene Chr17:35847609-35850418 (+)
DBA/2J ENSMUSG00185047863
 protein coding gene Chr2:153747790-153763310 (+)
FVB/NJ ENSMUSG00205022761
 protein coding gene Chr2:152807777-152823342 (+)
JF1/MsJ ENSUMUG00000017156
 protein coding gene Chr2:153404019-153419539 (+)
LP/J ENSMUSG00230042155
 protein coding gene Chr2:155341771-155357300 (+)
NOD/ShiLtJ ENSMUSG00190036446
 protein coding gene Chr2:153436525-153452088 (+)
NZO/HlLtJ ENSMUSG00225051666
 protein coding gene Chr2:163363411-163378971 (+)
PWK/PhJ ENSLUMG00010039659
 protein coding gene Chr2:153337369-153352894 (+)
SPRET/EiJ ENSMSPG00010034825
 protein coding gene Chr2:156123004-156139016 (+)
WSB/EiJ ENSIUOG00005043420
 protein coding gene Chr2:153126939-153142499 (+)



Homology
more
  • Human Ortholog
    TGIF2, TGFB induced factor homeobox 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGIF2, TGFB induced factor homeobox 2
  • Links
    NCBI Gene ID: 60436
    UniProt: Q9GZN2

  • Chr Location
    20q11.23; chr20:36571894-36593950 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are viable and do not display any gross defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1129
  • Tissues
    302
  • cDNA Data
    21
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062175 Ensembl Gene Model | MGI Sequence Detail 15564 C57BL/6J ±  kb
    transcript ENSMUST00000081335 Ensembl | MGI Sequence Detail 2900 Not Applicable  
    polypeptide ENSMUSP00000096745 Ensembl | MGI Sequence Detail 237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 22
      Primer pair 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139509, MGI:2139513
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory