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Rnf146 Gene Detail
Summary
  • Symbol
    Rnf146
  • Name
    ring finger protein 146
  • Synonyms
    2610509H23Rik, Iduna
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915281
    NCBI Gene: 68031
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:29220172-29238438 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 16.60 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    480 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915281
 protein coding gene Chr10:29220172-29238438 (-)
129S1/SvImJ ENSMUSG00200008459
 protein coding gene Chr10:26062941-26081186 (-)
A/J ENSMUSG00195013210
 protein coding gene Chr10:26344832-26363098 (-)
AKR/J ENSMUSG00220011035
 protein coding gene Chr10:26039509-26057775 (-)
BALB/cJ ENSMUSG00180016410
 protein coding gene Chr10:26469919-26488185 (-)
C3H/HeJ ENSMUSG00175025175
 protein coding gene Chr10:26205879-26224145 (-)
C57BL/6NJ ENSMUSG00215008642
 protein coding gene Chr10:26018116-26036384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015209
 protein coding gene Chr10:25218771-25236650 (-)
CAST/EiJ ENSTCUG00005013392
 protein coding gene Chr10:25845830-25864179 (-)
CBA/J ENSMUSG00210023295
 protein coding gene Chr10:26152561-26170827 (-)
DBA/2J ENSMUSG00185007204
 protein coding gene Chr10:26305246-26323512 (-)
FVB/NJ ENSMUSG00205009210
 protein coding gene Chr10:26296061-26314344 (-)
JF1/MsJ ENSUMUG00000013673
 protein coding gene Chr10:26106498-26124809 (-)
LP/J ENSMUSG00230011293
 protein coding gene Chr10:28073352-28091597 (-)
NOD/ShiLtJ ENSMUSG00190014959
 protein coding gene Chr10:26410496-26428762 (-)
NZO/HlLtJ ENSMUSG00225033191
 protein coding gene Chr10:32332286-32350552 (-)
PWK/PhJ ENSLUMG00010009212
 protein coding gene Chr10:25965571-25983890 (-)
SPRET/EiJ ENSMSPG00010014908
 protein coding gene Chr10:26893923-26912203 (-)
WSB/EiJ ENSIUOG00005030157
 protein coding gene Chr10:25782050-25797855 (-)



Homology
more
  • Human Ortholog
    RNF146, ring finger protein 146
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF146, ring finger protein 146
  • Links
    NCBI Gene ID: 81847
    UniProt: Q9NTX7

  • Chr Location
    6q22.33; chr6:127266582-127288567 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rnf146 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in immune cells exhibit osteopenia with enhanced osteoclastogenesis. Mice homozygous for a conditional allele activated in osteoblast exhibit ostepenia with impaired osteoblast numbers, increased adipogenesis and impaired glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    660
  • Tissues
    41
  • cDNA Data
    15
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68031 NCBI Gene Model | MGI Sequence Detail 18267 C57BL/6J ±  kb
    transcript NM_001110197 RefSeq | MGI Sequence Detail 4420 C57BL/6  
    polypeptide Q9CZW6 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 6
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346147 Hou S, et al., PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis. Mol Cell. 2024 Mar 7;84(5):938-954.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory