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Tmem86a Gene Detail
Summary
  • Symbol
    Tmem86a
  • Name
    transmembrane protein 86A
  • Synonyms
    1810054O13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915143
    NCBI Gene: 67893
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46700388-46704524 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915143
 protein coding gene Chr7:46700349-46704525 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032280
 protein coding gene Chr7:47466989-47471121 (+)
A/J MGP_AJ_G0032259
 protein coding gene Chr7:46478520-46482668 (+)
AKR/J MGP_AKRJ_G0032195
 protein coding gene Chr7:47796326-47800465 (+)
BALB/cJ MGP_BALBcJ_G0032271
 protein coding gene Chr7:46486122-46490282 (+)
C3H/HeJ MGP_C3HHeJ_G0031984
 protein coding gene Chr7:48269568-48274730 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032761
 protein coding gene Chr7:49756568-49760730 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029777
 protein coding gene Chr7:49017589-49021668 (+)
CAST/EiJ MGP_CASTEiJ_G0031312
 protein coding gene Chr7:39750450-39754574 (+)
CBA/J MGP_CBAJ_G0031949
 protein coding gene Chr7:51411902-51416073 (+)
DBA/2J MGP_DBA2J_G0032106
 protein coding gene Chr7:46154858-46159010 (+)
FVB/NJ MGP_FVBNJ_G0032060
 protein coding gene Chr7:45970856-45975210 (+)
LP/J MGP_LPJ_G0032187
 protein coding gene Chr7:48177296-48181428 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032097
 protein coding gene Chr7:50029282-50034588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032778
 protein coding gene Chr7:47003036-47007175 (+)
PWK/PhJ MGP_PWKPhJ_G0031037
 protein coding gene Chr7:39540054-39544237 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030875
 protein coding gene Chr7:35027384-35031442 (+)
WSB/EiJ MGP_WSBEiJ_G0031432
 protein coding gene Chr7:47526682-47530811 (+)



Homology
more
  • Human Ortholog
    TMEM86A, transmembrane protein 86A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM86A, transmembrane protein 86A
  • Links
    NCBI Gene ID: 144110
    neXtProt AC: NX_Q8N2M4
    UniProt: Q8N2M4

  • Chr Location
    11p15.1; chr11:18693122-18704785 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    18
  • cDNA Data
    42
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67893 NCBI Gene Model | MGI Sequence Detail 4137 C57BL/6J ±  kb
    transcript NM_026436 RefSeq | MGI Sequence Detail 1791 C57BL/6  
    polypeptide Q9D8N3 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 43
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141929, MGI:2142272
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:338239 van Wouw SAE, et al., Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. J Lipid Res. 2023 Feb;64(2):100325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory