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Mettl9 Gene Detail
Summary
  • Symbol
    Mettl9
  • Name
    methyltransferase like 9
  • Synonyms
    0610012D09Rik, Drev
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914862
    NCBI Gene: 59052
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:120633668-120677552 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 65.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914862
 protein coding gene Chr7:120631717-120677552 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032939
 protein coding gene Chr7:125053723-125096980 (+)
A/J MGP_AJ_G0032922
 protein coding gene Chr7:121790018-121832521 (+)
AKR/J MGP_AKRJ_G0032854
 protein coding gene Chr7:124914661-124957050 (+)
BALB/cJ MGP_BALBcJ_G0032927
 protein coding gene Chr7:121507527-121550227 (+)
C3H/HeJ MGP_C3HHeJ_G0032637
 protein coding gene Chr7:124830652-124873018 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033433
 protein coding gene Chr7:130000166-130042659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030405
 protein coding gene Chr7:123161980-123203994 (+)
CAST/EiJ MGP_CASTEiJ_G0031965
 protein coding gene Chr7:116593067-116635593 (+)
CBA/J MGP_CBAJ_G0032610
 protein coding gene Chr7:134329368-134374470 (+)
DBA/2J MGP_DBA2J_G0032762
 protein coding gene Chr7:119823432-119865821 (+)
FVB/NJ MGP_FVBNJ_G0032715
 protein coding gene Chr7:119682297-119724686 (+)
LP/J MGP_LPJ_G0032856
 protein coding gene Chr7:126494830-126537281 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032747
 protein coding gene Chr7:135794436-135837698 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033453
 protein coding gene Chr7:123908378-123951357 (+)
PWK/PhJ MGP_PWKPhJ_G0031673
 protein coding gene Chr7:112752463-112795074 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031519
 protein coding gene Chr7:110669369-110711649 (+)
WSB/EiJ MGP_WSBEiJ_G0032078
 protein coding gene Chr7:124834117-124876506 (+)



Homology
more
  • Human Ortholog
    METTL9, methyltransferase 9, His-X-His N1(pi)-histidine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL9, methyltransferase 9, His-X-His N1(pi)-histidine
  • Synonyms
    CGI-81, DREV, DREV1, hMETTL9, PAP1
  • Links
    NCBI Gene ID: 51108
    neXtProt AC: NX_Q9H1A3
    UniProt: Q9H1A3

  • Chr Location
    16p12.2; chr16:21597208-21657471 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit reduced 1MH methylation without any abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    9
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030876 Ensembl Gene Model | MGI Sequence Detail 43885 C57BL/6J ±  kb
transcript ENSMUST00000033163 Ensembl | MGI Sequence Detail 1823 Not Applicable  
polypeptide ENSMUSP00000033163 Ensembl | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010355 protein-L-histidine N-pros-methyltransferase
    (term hierarchy)
  • EC
    2.1.1.-
  • InterPro Domains
    IPR007884 Protein-L-histidine N-pros-methyltransferase
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:67662 Bates EE, et al., The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. Immunogenetics. 2000 Nov;52(1-2):112-20
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory