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Dhx40 Gene Detail
Summary
  • Symbol
    Dhx40
  • Name
    DEAH-box helicase 40
  • Synonyms
    2410016C14Rik, ARG147, DDX40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914737
    NCBI Gene: 67487
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86659672-86698572 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.82 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    225 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914737
 protein coding gene Chr11:86659672-86698695 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018895
 protein coding gene Chr11:88347419-88389779 (-)
A/J MGP_AJ_G0018862
 protein coding gene Chr11:84950027-84988471 (-)
AKR/J MGP_AKRJ_G0018832
 protein coding gene Chr11:87490880-87529237 (-)
BALB/cJ MGP_BALBcJ_G0018835
 protein coding gene Chr11:85330210-85369136 (-)
C3H/HeJ MGP_C3HHeJ_G0018649
 protein coding gene Chr11:87523151-87563372 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019287
 protein coding gene Chr11:91007542-91050641 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016920
 protein coding gene Chr11:81968649-82009271 (-)
CAST/EiJ MGP_CASTEiJ_G0018204
 protein coding gene Chr11:88208117-88249530 (-)
CBA/J MGP_CBAJ_G0018620
 protein coding gene Chr11:94835787-94876749 (-)
DBA/2J MGP_DBA2J_G0018728
 protein coding gene Chr11:84517923-84556712 (-)
FVB/NJ MGP_FVBNJ_G0018717
 protein coding gene Chr11:84018021-84057461 (-)
LP/J MGP_LPJ_G0018798
 protein coding gene Chr11:88834196-88873624 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018744
 protein coding gene Chr11:94938030-94983820 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019327
 protein coding gene Chr11:87736907-87776118 (-)
PWK/PhJ MGP_PWKPhJ_G0017974
 protein coding gene Chr11:85316938-85356441 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017766
 protein coding gene Chr11:87288050-87328173 (-)
WSB/EiJ MGP_WSBEiJ_G0018255
 protein coding gene Chr11:87608057-87647506 (-)



Homology
more
  • Human Ortholog
    DHX40, DEAH-box helicase 40
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX40, DEAH-box helicase 40
  • Synonyms
    ARG147, DDX40, PAD
  • Links
    NCBI Gene ID: 79665
    neXtProt AC: NX_Q8IX18
    UniProt: Q8IX18

  • Chr Location
    17q23.1; chr17:59565558-59608345 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    22
  • cDNA Data
    92
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018425 Ensembl Gene Model | MGI Sequence Detail 38901 C57BL/6J ±  kb
    transcript ENSMUST00000018569 Ensembl | MGI Sequence Detail 3813 Not Applicable  
    polypeptide ENSMUSP00000018569 Ensembl | MGI Sequence Detail 779 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000032512 probable ATP-dependent RNA helicase DHX40
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011709 DEAD-box helicase, OB fold
      IPR011545 DEAD/DEAH box helicase domain
      IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
      IPR007502 Helicase-associated domain
      IPR048333 Helicase associated domain (HA2), winged-helix domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 93

      Microarray probesets 4
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory