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Far1 Gene Detail
Summary
  • Symbol
    Far1
  • Name
    fatty acyl CoA reductase 1
  • Synonyms
    2600011M19Rik, 2900034E22Rik, 3732409C05Rik, Mlstd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914670
    NCBI Gene: 67420
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:113113041-113170718 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 59.21 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1075 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914670
 protein coding gene Chr7:113113008-113170718 (+)
129S1/SvImJ ENSMUSG00200030061
 protein coding gene Chr7:99659943-99717617 (+)
A/J ENSMUSG00195038756
 protein coding gene Chr7:104164422-104222098 (+)
AKR/J ENSMUSG00220037148
 protein coding gene Chr7:97567300-97624976 (+)
BALB/cJ ENSMUSG00180034953
 protein coding gene Chr7:100832437-100890113 (+)
C3H/HeJ ENSMUSG00175020852
 protein coding gene Chr7:101458367-101517327 (+)
C57BL/6NJ ENSMUSG00215049745
 protein coding gene Chr7:100775045-100832726 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030342
 protein coding gene Chr7:115760501-115817564 (+)
CAST/EiJ ENSTCUG00005036617
 protein coding gene Chr7:104145087-104209174 (+)
CBA/J ENSMUSG00210024191
 protein coding gene Chr7:101285294-101344250 (+)
DBA/2J ENSMUSG00185021388
 protein coding gene Chr7:105635506-105694460 (+)
FVB/NJ ENSMUSG00205023286
 protein coding gene Chr7:101254487-101312157 (+)
JF1/MsJ ENSUMUG00000021318
 protein coding gene Chr7:110662704-110721697 (+)
LP/J ENSMUSG00230033131
 protein coding gene Chr7:111746294-111803968 (+)
NOD/ShiLtJ ENSMUSG00190020894
 protein coding gene Chr7:101461727-101519401 (+)
NZO/HlLtJ ENSMUSG00225014658
 protein coding gene Chr7:109969024-110027984 (+)
PWK/PhJ ENSLUMG00010034206
 protein coding gene Chr7:99807192-99864799 (+)
SPRET/EiJ ENSMSPG00010037956
 protein coding gene Chr7:100981977-101039088 (+)
WSB/EiJ ENSIUOG00005011856
 protein coding gene Chr7:102101193-102158817 (+)



Homology
more
  • Human Ortholog
    FAR1, fatty acyl-CoA reductase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAR1, fatty acyl-CoA reductase 1
  • Synonyms
    CSPSD, MLSTD2, PFCRD, SDR10E1
  • Links
    NCBI Gene ID: 84188
    UniProt: Q8WVX9

  • Chr Location
    11p15.3; chr11:13667462-13732367 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FAR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial preweaning lethality, postnatal growth retardation, small testes, and male infertility associated with azoospermia, spermatogenesis arrest, disrupted intercellular bridge formation, multinucleated giant germ cells, and increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030759 Ensembl Gene Model | MGI Sequence Detail 57678 C57BL/6J ±  kb
    transcript ENSMUST00000033018 Ensembl | MGI Sequence Detail 4962 Not Applicable  
    polypeptide ENSMUSP00000033018 Ensembl | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1917555, MGI:1920154, MGI:2142053
    References
    more
    • Summaries
      All 50
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory