About   Help   FAQ
Ppil4 Gene Detail
Summary
  • Symbol
    Ppil4
  • Name
    peptidylprolyl isomerase (cyclophilin)-like 4
  • Synonyms
    3732410E19Rik, 3830425H19Rik, PPIase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914668
    NCBI Gene: 67418
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:7668653-7698329 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    931 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914668
 protein coding gene Chr10:7668653-7698899 (+)
129S1/SvImJ ENSMUSG00200008839
 protein coding gene Chr10:4664057-4694255 (+)
A/J ENSMUSG00195008795
 protein coding gene Chr10:4552790-4582994 (+)
AKR/J ENSMUSG00220007173
 protein coding gene Chr10:4671115-4701312 (+)
BALB/cJ ENSMUSG00180021109
 protein coding gene Chr10:4714874-4745076 (+)
C3H/HeJ ENSMUSG00175012317
 protein coding gene Chr10:4703730-4734022 (+)
C57BL/6NJ ENSMUSG00215005050
 protein coding gene Chr10:4606873-4637124 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015103
 protein coding gene Chr10:4363988-4397152 (+)
CAST/EiJ ENSTCUG00005017020
 protein coding gene Chr10:4675473-4705943 (+)
CBA/J ENSMUSG00210012362
 protein coding gene Chr10:4649395-4679684 (+)
DBA/2J ENSMUSG00185009446
 protein coding gene Chr10:4695881-4726172 (+)
FVB/NJ ENSMUSG00205008447
 protein coding gene Chr10:4648896-4679192 (+)
JF1/MsJ ENSUMUG00000028207
 protein coding gene Chr10:4783035-4815500 (+)
LP/J ENSMUSG00230016157
 protein coding gene Chr10:6313807-6344002 (+)
NOD/ShiLtJ ENSMUSG00190023553
 protein coding gene Chr10:4640949-4671241 (+)
NZO/HlLtJ ENSMUSG00225016016
 protein coding gene Chr10:10833862-10864161 (+)
PWK/PhJ ENSLUMG00010020160
 protein coding gene Chr10:4515136-4547949 (+)
SPRET/EiJ ENSMSPG00010006349
 protein coding gene Chr10:4872460-4905078 (+)
WSB/EiJ ENSIUOG00005013335
 protein coding gene Chr10:4577934-4608152 (+)



Homology
more
  • Human Ortholog
    PPIL4, peptidylprolyl isomerase like 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPIL4, peptidylprolyl isomerase like 4
  • Synonyms
    HDCME13P
  • Links
    NCBI Gene ID: 85313
    UniProt: Q8WUA2

  • Chr Location
    6q25.1; chr6:149504495-149546092 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    22
  • cDNA Data
    82
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67418 NCBI Gene Model | MGI Sequence Detail 29677 C57BL/6J ±  kb
transcript NR_190739 RefSeq | MGI Sequence Detail 3026 C57BL/6  
polypeptide Q9CXG3 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013086 peptidyl-prolyl cis-trans isomerase-like 4
    (term hierarchy)
  • EC
    5.2.1.8
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR035542 Cyclophilin-RNA interacting protein
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035538 PPIL4-like, cyclophilin domain
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
  • GlyGen
    Q9CXG3 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 85
    cDNA 82
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1923985, MGI:2143669, MGI:2143821
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:363513 Chen H, et al., The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway. Cell Rep. 2025 Feb 25;44(2):115231
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory