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Ascl4 Gene Detail
Summary
  • Symbol
    Ascl4
  • Name
    achaete-scute family bHLH transcription factor 4
  • Synonyms
    1700054F16Rik, bHLHa44
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914591
    NCBI Gene: 67341
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:85763266-85765513 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914591
 protein coding gene Chr10:85763266-85782070 (+)
129S1/SvImJ ENSMUSG00200028240
 protein coding gene Chr10:82260491-82279018 (+)
A/J ENSMUSG00195018592
 protein coding gene Chr10:82707705-82726236 (+)
AKR/J ENSMUSG00220020420
 protein coding gene Chr10:82310003-82328535 (+)
BALB/cJ ENSMUSG00180028368
 protein coding gene Chr10:82710821-82729348 (+)
C3H/HeJ ENSMUSG00175022496
 protein coding gene Chr10:82586666-82605192 (+)
C57BL/6NJ ENSMUSG00215025115
 protein coding gene Chr10:82255139-82273667 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015688
 protein coding gene Chr10:79802130-79822116 (+)
CAST/EiJ ENSTCUG00005033362
 protein coding gene Chr10:81999295-82024413 (+)
CBA/J ENSMUSG00210032227
 protein coding gene Chr10:82437403-82455932 (+)
DBA/2J ENSMUSG00185037968
 protein coding gene Chr10:82651473-82669999 (+)
FVB/NJ ENSMUSG00205014172
 protein coding gene Chr10:82314529-82333058 (+)
JF1/MsJ ENSUMUG00000008657
 protein coding gene Chr10:84008732-84027345 (+)
LP/J ENSMUSG00230017235
 protein coding gene Chr10:84543905-84562439 (+)
NOD/ShiLtJ ENSMUSG00190016452
 protein coding gene Chr10:82693357-82711883 (+)
NZO/HlLtJ ENSMUSG00225048962
 protein coding gene Chr10:88816609-88835134 (+)
PWK/PhJ ENSLUMG00010021200
 protein coding gene Chr10:82285073-82303633 (+)
SPRET/EiJ ENSMSPG00010031461
 protein coding gene Chr10:83742720-83744111 (+)
WSB/EiJ ENSIUOG00005032635
 protein coding gene Chr10:82382907-82401447 (+)



Homology
more
  • Human Ortholog
    ASCL4, achaete-scute family bHLH transcription factor 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASCL4, achaete-scute family bHLH transcription factor 4
  • Synonyms
    ASH-4, bHLHa44, HASH4
  • Links
    NCBI Gene ID: 121549
    UniProt: Q6XD76

  • Chr Location
    12q23.3; chr12:107774704-107776644 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    618
  • Tissues
    14
  • cDNA Data
    3
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67341 NCBI Gene Model | MGI Sequence Detail 2248 C57BL/6J ±  kb
    transcript NM_001163614 RefSeq | MGI Sequence Detail 2248 C57BL/6  
    polypeptide NP_001157086 RefSeq | MGI Sequence Detail 144 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR050283 E-box Binding Transcriptional Regulators
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 3
      Primer pair 1
      Other 1
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350462 Papagno V, et al., Wnt target gene Ascl4 is dispensable for skin appendage development. Int J Dev Biol. 2024 May 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory