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Stk35 Gene Detail
Summary
  • Symbol
    Stk35
  • Name
    serine/threonine kinase 35
  • Synonyms
    1700054C12Rik, CLIK1, CLP-36 interacting kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914583
    NCBI Gene: 67333
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129642437-129674207 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    720 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914583
 protein coding gene Chr2:129642437-129674207 (+)
129S1/SvImJ ENSMUSG00200044892
 protein coding gene Chr2:126688208-126720110 (+)
A/J ENSMUSG00195027901
 protein coding gene Chr2:126717559-126749332 (+)
AKR/J ENSMUSG00220040467
 protein coding gene Chr2:126482009-126513913 (+)
BALB/cJ ENSMUSG00180046792
 protein coding gene Chr2:126507899-126540562 (+)
C3H/HeJ ENSMUSG00175042374
 protein coding gene Chr2:127059966-127091739 (+)
C57BL/6NJ ENSMUSG00215030564
 protein coding gene Chr2:126565741-126597515 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024290
 protein coding gene Chr2:122598864-122629925 (+)
CAST/EiJ ENSTCUG00005035734
 protein coding gene Chr2:125841994-125873989 (+)
CBA/J ENSMUSG00210032063
 protein coding gene Chr2:126916896-126948665 (+)
DBA/2J ENSMUSG00185030991
 protein coding gene Chr2:126570593-126602366 (+)
FVB/NJ ENSMUSG00205031606
 protein coding gene Chr2:125736583-125768489 (+)
JF1/MsJ ENSUMUG00000011684
 protein coding gene Chr2:126396579-126428359 (+)
LP/J ENSMUSG00230035011
 protein coding gene Chr2:128323447-128355349 (+)
NOD/ShiLtJ ENSMUSG00190012324
 protein coding gene Chr2:126672375-126704150 (+)
NZO/HlLtJ ENSMUSG00225027342
 protein coding gene Chr2:136232252-136264154 (+)
PWK/PhJ ENSLUMG00010037302
 protein coding gene Chr2:126327707-126362762 (+)
SPRET/EiJ ENSMSPG00010025620
 protein coding gene Chr2:128719734-128747715 (+)
WSB/EiJ ENSIUOG00005042568
 protein coding gene Chr2:126495955-126527872 (+)



Homology
more
  • Human Ortholog
    STK35, serine/threonine kinase 35
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK35, serine/threonine kinase 35
  • Synonyms
    CLIK1, STK35L1
  • Links
    NCBI Gene ID: 140901
    UniProt: Q8TDR2

  • Chr Location
    20p13; chr20:2101767-2177038 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal gametogenesis, eye defects and partial lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    24
  • cDNA Data
    51
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67333 NCBI Gene Model | MGI Sequence Detail 31771 C57BL/6J ±  kb
    transcript NM_183262 RefSeq | MGI Sequence Detail 6204 C57BL/6  
    polypeptide Q80ZW0 UniProt | EBI | MGI Sequence Detail 539 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 54
      Primer pair 3
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory