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Plekho1 Gene Detail
Summary
  • Symbol
    Plekho1
  • Name
    pleckstrin homology domain containing, family O member 1
  • Synonyms
    2810052M02Rik, CKIP-1, Jza2, JZA-20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914470
    NCBI Gene: 67220
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95896110-95903258 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 41.65 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914470
 protein coding gene Chr3:95895741-95903313 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027602
 protein coding gene Chr3:96782345-96795011 (-)
A/J MGP_AJ_G0027561
 protein coding gene Chr3:93746152-93753699 (-)
AKR/J MGP_AKRJ_G0027528
 protein coding gene Chr3:95941417-95948984 (-)
BALB/cJ MGP_BALBcJ_G0027573
 protein coding gene Chr3:93531176-93538456 (-)
C3H/HeJ MGP_C3HHeJ_G0027306
 protein coding gene Chr3:96236936-96246147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028021
 protein coding gene Chr3:100334710-100342282 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025361
 protein coding gene Chr3:90072819-90080350 (-)
CAST/EiJ MGP_CASTEiJ_G0026756
 protein coding gene Chr3:95524999-95534135 (-)
CBA/J MGP_CBAJ_G0027283
 protein coding gene Chr3:104015199-104026460 (-)
DBA/2J MGP_DBA2J_G0027422
 protein coding gene Chr3:93045371-93052938 (-)
FVB/NJ MGP_FVBNJ_G0027393
 protein coding gene Chr3:91121071-91130410 (-)
LP/J MGP_LPJ_G0027531
 protein coding gene Chr3:98093017-98104042 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027420
 protein coding gene Chr3:110126511-110136048 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028075
 protein coding gene Chr3:95579834-95589112 (-)
PWK/PhJ MGP_PWKPhJ_G0026484
 protein coding gene Chr3:92939262-92946815 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026305
 protein coding gene Chr3:93876198-93883653 (-)
WSB/EiJ MGP_WSBEiJ_G0026838
 protein coding gene Chr3:95978198-95988592 (-)



Homology
more
  • Human Ortholog
    PLEKHO1, pleckstrin homology domain containing O1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHO1, pleckstrin homology domain containing O1
  • Synonyms
    CKIP1, CKIP-1, JBP, OC120
  • Links
    NCBI Gene ID: 51177
    neXtProt AC: NX_Q53GL0
    UniProt: Q53GL0

  • Chr Location
    1q21.2; chr1:150149183-150164720 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit age-dependent increase in bone volume and increased osteoblast activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    69
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67220 NCBI Gene Model | MGI Sequence Detail 7149 C57BL/6J ±  kb
    transcript NM_023320 RefSeq | MGI Sequence Detail 1507 C57BL/6  
    polypeptide Q9JIY0 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012865 pleckstrin homology domain-containing family O member 1
      (term hierarchy)
    • InterPro Domains
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR043448 Pleckstrin homology domain-containing family O member 1/2
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 69

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35895, MGI:107424
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 20
    • Earliest
      J:33282 Chevray PM, et al., Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5789-93
    • Latest
      J:334215 Yang Y, et al., The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article). Biochem Pharmacol. 2022 Nov 5;206:115339
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory